帕瑞昔布钠对脊柱侧凸矫形术后芬太尼镇痛效果的影响

Effects of parecoxib on postoperative analgesic efficacy of fentanyl after scoliosis correction surgery

目的 观察帕瑞昔布纳对脊柱侧凸矫形术后芬太尼镇痛效果的影响.方法 择期行脊柱侧凸矫形术患者40例,随机均分为P、C两组.脊柱矫形内固定完成后,P组静注帕瑞昔布钠40mg或0.8 mg/kg,C组静注生理盐水2 ml.术毕均采用芬太尼自控静脉镇痛.记录术后2、6、12、24和48 h的VAS评分和PCA按压总次数、有效次数,术后12、24和48 h芬太尼用量和不良反应.结果 P组术后2、6、12和24 hVAS评分、PCA按压总次数和有效次数及术后12、24和48 h芬太尼用量均少于C组（P〈0.05或P〈0.01）.两组不良反应的差异无统计学意义.结论 脊柱侧凸矫形术后应用帕瑞昔布钠可增强芬太尼镇痛效果,减少芬太尼用量.

Objective To observe the effects of parecoxib on postoperative analgesic efficacy of fentanyl after scoliosis correction surgery. Methods Forty patients undergoing scoliosis correction surgery were equally randomized into two groups. After spine fusion, group P received parecoxib sodium 40 mg or 0. 8 mg/kg, while group C received normal saline 2 ml. PCA with fentanyl was used for postoperative analgesia in all patients. VAS, the number of total demand, and the number of successfully delivered doses were recorded at 2, 6, 12, 24, and 48 h after operation. The fentanyl consumption as well as adverse effects was recorded at 12, 24, and 48 h after operation. Results VAS, the number of total demand and the number of successfully delivered doses at 2, 6, 12, and 24 h after operation, and the fentanyl consumption at 12, 24 and 48 h after operation were lower in group P than group C （P^0. 05 or P^0. 01）. Adverse effects had no significant difference between the two groups. Conclusion Parecoxib can enhance the postoperative analgesic efficacy of fentanyl after scoliosis correction surgery and spare the fentanyl consumption.