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PK-PD模型在静脉麻醉中的应用 被引量：1

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摘要 现代药理学研究的主要内容由药动学和药效学构成。药物动力学（PK）是研究药物体内过程动态规律的科学；药效学是研究药物对机体的作用原理与规律的科学，描述随着浓度变化出现的药理效应，并对效应的时间过程进行分析。单一的药物动力学或药效学无法很好描述药物浓度-时间-效应三者之间的关系，必须把两者结合起来。因此，
作者 李岩 张卫
机构地区 郑州大学第一附属医院麻醉科
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2010年第5期457-459,共3页 Journal of Clinical Anesthesiology
关键词 静脉麻醉 PD模型 药物体内过程 药物动力学 应用 药物浓度 现代药理学 时间-效应
分类号 R614 [医药卫生—麻醉学]
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参考文献10

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二级参考文献19

  • 1舒芬太尼多中心研讨会纪要[J].临床麻醉学杂志,2004,20(11):668-668. 被引量：48
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共引文献12

同被引文献4

  • 1Ortolani O,Conti A,Chan YK,etal.Comparison of propofol consumption and recovery time in Caucasians from Italy, with Chinese,Malays arrd Indians from Malaysia[J].Anaesth Intensive Care,2004,329(2):250-255.
  • 2Bekker A,Sturaitis M o Dexmedetomidine for neurological suegery.[J]Neurosugery.2005.57:1-10.
  • 3Wang H.Tompkins LM.CYP2B6:new insights into a historically overlooked cytochrome P450 isozyme.Curr Drud Metab,2008,9:598-610.
  • 4Hu C,Horstman DJ,Shafer SL.Variability of target-controlled infusion is less than the variability after bolus injection[J]. Anesthesiology,2005; 102(3):639.

引证文献1

临床麻醉学杂志
2010年 第5期

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