重症肺炎患者血脂水平与APACHE Ⅱ评分及预后的相关性

The correlations of circulating lipids levels with APACHE Ⅱ score and prognosis in patients with severe pneumonia

目的 研究重症肺炎患者血脂水平与急性生理学及慢性健康状况评分Ⅱ（APACHE Ⅱ）的相关性及在预后中的预测价值.方法 选取63例重症肺炎患者,检测其血脂水平,评估其APACHE Ⅱ,分析血脂各指标[HDL、LDL、总胆固醇（TC）、甘油三酯（TG）]与APACHE Ⅱ的相关性.另外,根据检测结果将患者分为好转组及恶化组,比较两组患者的血脂水平.结果 所有患者HDL、LDL、TC、TG分别为（1.00±0.52）、（1.67±0.88）、（3.13±1.18）、（1.33±1.01）mmol/L,APACH Ⅱ为（28.71±9.48）分.相关分析结果显示,重症肺炎患者血清HDL、LDL和TC与APACHE Ⅱ均呈显著性负相关（P〈0.01）,而TG与APACHE Ⅱ无明显相关性（P＞0.05）.好转组患者HDL、LDL、TC水平均显著高于恶化组（P〈0.01）.结论 重症肺炎患者血脂水平与APACHE Ⅱ评分存在明显的负相关,血脂水平对重症肺炎的预后可能有一定的预测作用.

Objective To investigate the correlation of blood lipids levels and APACHE Ⅱ score and prognosis in patients with severe pneumonia. Methods The blood concentrations of lipids were measured in 63 patients with severe pneumonia and the correlation of circulation lipids levels with APACHE Ⅱ score the prognosis of patients was evaluated. Results In severe pneumonia patients, the blood concentrations of HDL, LDL, TC and TG were （1.00 ± 0.52） mmol/L, （1.67 ± 0.88）mmol/L, （3.13 ± 1.18） mmol/L and （1.33 ±1.01） mmol/L respectively and APACHE II score was 28.71 ±9.48. The APACHE II score was negatively correlated with blood HDL, LDL and TC levels, but not with TG; and also the prognosis of severe pneumonia patients was significantly correlated with blood HDL, LDL and TC levels. Conclusion Blood lipids levels are negatively correlated with APACHE Ⅱ score and of value in prognosis of patients with severe pneumonia.