远端胆管癌切除患者术后生存的影响因素分析

Prognosis of distal bile duct cancer patients afar surgical resection

目的 研究影响远端胆管癌手术预后的因素,为远端胆管癌手术方式的选择和治疗提供依据.方法 对北京世纪坛医院、北京大学人民医院和北京大学第一医院1995-2009年具有完整随访资料的103例远端胆管癌病例进行回顾性分析,应用Kaplan-Meier单因素分析法和Cox比例风险模型多因素分析法对10个可能对预后产生影响的因素进行分析.结果 1、3、5年总体生存率分别为72%、41%和25%,中位生存期为24.13个月 单因素方差分析结果表明手术方式、淋巴结转移、TNM分期和切缘情况与远端胆管癌术后生存有关 Cox比例风险模型多因素分析结果表明切缘情况、淋巴结转移和TNM分期是影响远端胆管癌切除术后预后的独立因素.结论 切缘情况、淋巴结转移和TNM分期为远端胆管癌切除术后有关生存影响的独立因素,胰十二指肠切除术为远端胆管癌首选的手术方式.

Objective To study prognostic factors after surgical resection for distal bile duct cancer. Methods A retrospective muhicenter clinical analysis,including Beijing Shijitan Hospital,Peking University People＇s Hospital and Peking University First Hospital,was made for 103 patients of distal bile duct cancer receiving surgical resection from 1995 to 2009.Potential clinicopathological prognostic factors were examined bv univariate and multivariate survival analysis. Results The 1.3 and 5 years overall survival rate was 72%,41%and 25% respectively （median survival time,24.13 months）.Univariate analysis revealed operative modality,lymph node status,surgical margin and TNM stage as significant factors influencing postoperative survival.Positive surgical margin,lymph node metastasis and TNM stage were significant independent predictors of poor prognosis by a Cox proportional hazards regression model. Condusions Surgical margin margin,lymph node metastasis and TNM stage were the most important prognostic factors for bile duct carcinoma after resection.Radical pancreaticoduodenectomy was the choice of therapy for distal bile duct carcinoma.