摘要
目的：探讨益肾生血片治疗再生障碍性贫血（再障）的作用机理。方法：观察了该药对小鼠造血功能、免疫功能、抗感染力和抵抗力的影响。结果：益肾生血片对马利兰引起的造血损伤小鼠多能造血干细胞（ＣＦＵＳ）、粒系祖细胞（ＣＦＵＣ）和红系祖细胞（ＣＦＵＥ）的数量的恢复有明显促进作用；对正常小鼠腹腔巨噬细胞吞噬功能有明显促进作用；可明显降低接种金黄色葡萄球菌小鼠的死亡率；在常压缺氧时，可使小鼠耐缺氧能力明显提高，存活时间延长。结论：益肾生血片治疗再障有效可能是通过促进骨髓造血干细胞增殖，提高机体非特异性免疫力、抗感染力和抵抗力几方面作用来实现的。
Objective: To study the mechanism of
Yishen Shengxue Tablet (YSSXT) in treating aplastic anemia. Methods: Observing the effect of
YSSXT on hematopoietic, immunologic, anti infection and body resistance of model mice of
aplastic anemia. Results: YSSXT had marked effect of promotion on recovering myleran injury
induced reduction of colony forming unit spleen (CFU S), colony forming unit culture (CFU C),
colony forming unit erythrocyte (CFU E), markedly promoting the peritoneal macrophage
phagocytosis of normal mice, also markedly lower the mortality of Staphylococcus aureus
inoculated mice, and elevate the anoxia resistant ability under normal pressure of anoxic mice,
prolonging their survival time. Conclusion: Using YSSXT to treat aplastic anemia that the
effectiveness might be realized through promoting the proliferation of hematopoietic stem cells
of bone marrow, enhancing the non specific immunity, and the anti infectionn as well as body
resistance.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1999年第3期170-173,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
益肾生血片
再生障碍性贫血
中医药疗法
Yishen Shengxue tablet, aplastic anemia, hematopoietic stem cell,
immunologic function, anti infection ability
