原发性高血压患者巨细胞病毒感染及与血管并发症关系的研究

The study on cytomegalovirus infection associated with vascular complications in patients with essential hypertension

目的探讨原发性高血压患者巨细胞病毒感染及与血管并发症之间的关系。方法应用间接酶联免疫吸附试验（ＥＬＩＳＡ）检测了１０５例原发性高血压患者血清人巨细胞病毒（ＨＣＭＶ）特异性抗体。结果ＨＣＭＶＩｇＭ和ＩｇＡ抗体的阳性率分别为２６．６７％和２０．９５％，明显高于对照组（６．６７％），经统计学处理，原发性高血压Ⅲ期组活动性ＨＣＭＶＩｇＭ抗体阳性率（４５．７１％）与Ⅰ＋Ⅱ期（１７．１４％）相比有显著性差异（Ｐ＜０．０１）。血管并发症组活动性ＨＣＭＶ感染率（７１．４３％）显著高于无血管并发症组（１８．８４％）。结论研究结果提示原发性高血压患者存在较高的活动性巨细胞病毒感染，ＨＣＭＶ活动性感染似与血管并发症有一定关联。

Objective This paper studied HCMV infection inpatients with essential hupertension and the relationship of HCMV infection with vascular complications.Methods Indirect ELISA method was used to detect human cytomegalovirus (HCMV) specific antibodies in sera of 105 patients with essential hypertension.Results The results showed that the positive rates of active HCMV IgM and IgA antibodies were 26.67% and 20.95%, respectively, higher than that of the control group (6.67%). The positive rate of HCMV active IgM antiboey in Ⅲ stage groug was significantly higher than that of Ⅰ+Ⅱ stage groups ( P <0.01).Active HCMV infecitve rate was highetr in patients with vascular complifcation. Conclusion These results suggested that HCMV active infection may be associated with vascular complication.