丙泊酚-氯诺昔康镇痛对清宫术后子宫收缩痛的影响

Effect of propofol with lornoxicam on postoperative pain of dilatation and curettage

目的评价丙泊酚-氯诺昔康减轻清宫术后子宫收缩痛的效果。方法 90例ASAⅠ或Ⅱ级清宫手术患者随机分为研究组(45例)和对照组(45例)。研究组先缓慢静脉注射氯诺昔康8mg,10min后静脉注射丙泊酚2mg.kg-1;对照组先缓慢静脉注射芬太尼1μg.kg-1,10min后静脉注射丙泊酚2mg.kg-1。记录起效时间、苏醒时间、自行离床时间和丙泊酚总量,观察两组呼吸循环参数变化,采用VAS评分法评定术后镇痛效果。结果研究组患者苏醒即刻、苏醒后15min及30min宫缩痛的VAS评分均明显低于对照组,差异有统计学意义(P<0.05);研究组患者用药后2min和术后即刻SpO2均明显高于对照组,差异有统计学意义(P<0.05)。结论丙泊酚-氯诺昔康能有效减轻清宫术后的子宫收缩痛,值得临床推广应用。

OBJECTIVE To evaluate the effect of propofol with lornoxicam on reducing the postoperative pain of dilatation and curettage.METHODS 90 patients with ASA Ⅰor Ⅱ undergoing dilatation and curettage were randomly divided into study group（45 cases） and control group（45 cases）.The study group was administrated intravenously lornoxicam 8mg followed by propofol 2mg·kg-1 10 minutes later,while the control group was administrated intravenously fentanyl 1μg·kg-1 followed by propofol 2mg·kg-1 10 minutes later.Record onset time,wake time,away from the bed on their own time and the total amount of propofol,observe the change of respiratory and circulatory parameters and assess the analgesic effect by VAS scores.RESULTS The VAS scores of study group at wake up instantly,and awakens in 15 min and 30 min after were significantly lower than the control group,the difference was statistically significant（P0.05）;the SpO2 of study group 2min and immediately after treatment were significantly higher than control group,the difference was statistically significant（P0.05）.CONCLUSION Propofol-lornoxicam can effectively reduce the postoperative pain of dilatation and curettage,it is worthy to be popularized.