重症肌无力中血清白介素-4、15、18的表达及意义

Interleukin-4,15,18 Expression and Significance in Myasthenia Gravis

目的探讨白细胞价素(IL)-4、IL-15、IL-18与重症肌无力(MG)的关系。方法应用ELISA检测30例MG患者(重症肌无力组)和30例健康对照者(健康对照组)血清中的IL-4、IL-15、IL-18水平及乙酰胆碱受体抗体(AchRab)和突触前膜受体抗体(PsmRab)水平。结果重症肌无力组血清IL-4、IL-15、IL-18水平显著高于健康对照组,差异具有显著性(P<0.01);10例MG患者经治疗后血清的IL-4、IL-15、IL-18水平均较治疗前明显降低,差异具有显著性(P<0.05);重症肌无力组血清IL-4、IL-15、IL-18水平与临床绝对评分、病程、AchRab和PsmRab水平均无相关性(P>0.05);重症肌无力组全身型血清IL-18水平高于眼肌型血清IL-18水平,差异具有显著性(P<0.05),而血清IL-4、IL-15水平与临床分型无相关性(P>0.05);重症肌无力组血清IL-4、IL-15及IL-18水平两两之间均存在正相关关系(P<0.05)。结论 IL-4、IL-15、IL-18均参与了MG的发病过程,且其降低可以作为免疫治疗效果有意义的观察指标。

Objective To explore the relationship of IL-4,IL-15,IL-18 in serum levels of myasthenia gravis（MG）. Methods The serum levels of IL-4,IL-15,IL-18,AchRab and Psmab were detected with ELISA in 30 MG patients and 30 negative controls. Results The levels of IL-4,IL-15,IL-18 in MG were significantly higer than those in negative controls（P0.01）;The serum levels of IL-4,IL-15,IL-18 were decreased after immunochemitherapy（P0.05）;There were no correlations between the serum levels of IL-4,IL-15,IL-18 and the clinical absolute scores,course,serum levels of the AchRab,Psmab in MG patients（P0.05）;The IL-18 level of sys-type was significantly higer than that of ocular type（P0.05）,but there were no correlations between the serum levels of IL-4,IL-15 and grouping in MG patients（P0.05）;There were positive correlations between the serum levels of IL-4,IL-15 and IL-18（P0.05）. Conclusions（1） IL-4,IL-15,IL-18 were involved in the pathology of MG.The decreasing of IL-4,IL-15,IL-18 were significant in observing the effect of therapy on MG.