胶原酶联合臭氧注射治疗椎间盘突出症临床观察

A Clinical Report of Oxygen-ozone Combined With Collagenase Chemonucleolysis in the Treatment of Lumbar Disc Herniation

目的探讨胶原酶联合臭氧注射治疗腰椎间盘突出症的安全性及临床疗效。方法 161例腰椎间盘突出症患者随机分为联合治疗组(胶原酶联合臭氧注射,81例)和对照组(单纯胶原酶注射,80例),观察术后不良反应、并发症及3个月后的临床疗效。结果两组优良率分别为91.4%、90.0%(P>0.05),联合治疗组不良反应明显少于对照组(P<0.05)。结论胶原酶联合臭氧治疗腰椎间盘突出症能减少胶原酶化学溶解术的不良反应,是一种比较理想的微创介入治疗方法。

Objective To assess effect of percutaneous intradiscal oxygen-ozone injection combined with target collagenase chemonucleolysis in the treatment of lumbar disc herniation.Methods 161 patients with lubar intervertebral disc protrusion（LIDP） were divided into two groups randomly.A group of patients（n=81） were treated with collagenase combined oxygen-ozone therapy,but B group of patients（n=80） were treated with collagenase only.After treatment,the patients were followed-up and the adverse effect,complication and therapeutic effect were assessed at 3 months.Results The success rate was 91.4%,90.0% in two groups respectively.There was no statistically significant difference between two groups after 3 months（P0.05）.But the adverse effect in A group was less than in B group and there was a statistically significant difference between two groups（P0.05）. Conclusion The combination of the collagenase with oxygen-ozone shows significant reductions in adverse effect of collagenase chemonucleolysis,which can be considered as an option for the treatment of lumbar disc herniation.