奥沙利铂联合羟喜树碱治疗复发性卵巢上皮癌应用研究

Applied research of L-OHP combined with HCPT In recurrent epithelial ovarian cancer

目的:探讨奥沙利铂(L-OHP)联合羟喜树碱(HCPT)治疗复发性卵巢上皮癌的效果及毒副作用。方法:选择我院2000年1月―2006年1月复发的卵巢上皮癌66例患者应用奥沙利铂联合羟喜树碱治疗,同期相同诊断52例作为对照组,应用PAC-1方案治疗。疗程结束后,比较分析症状体征、肿瘤大小、肿瘤标志物(CA125)、血常规、尿常规、肝肾功能、心电图及毒副作用,1年和3年后随访存活率。结果:两组疗程结束后,治疗组各指标明显优于对照组。结论:奥沙利铂联合羟喜树碱治疗复发性卵巢上皮癌疗效确切,使用安全,副作用少,可以替代传统化疗方法,值得临床推广使用。

Objective：To investigate effects and side effects of L-OHP combined with HCPT in recurrent epithelial ovarian cancer.Methods：The patients with epithelial ovarian cancer in January 2000-2006 years,66 cases that treated by L-OHP combined with HCPT,52 cases treated by PAC-1.Results：The two groups after treatment,Treatment group are much higher than the control group.Conclusion：L-OHP combined with HCPT treatment of recurrent epithelial ovarian cancer is effective,safe,few side effects,can replace traditional chemotherapy,is worthy of clinical use.