网膜素与肥胖及胰岛素抵抗的关系

Relationship between omentin and obesity, insulin resistance

网膜素是新近发现的一种脂肪细胞因子，特异性表达于内脏脂肪组织。目前研究表明，网膜素能促进皮下和网膜脂肪细胞胰岛素刺激的葡萄糖转运和蛋白激酶B磷酸化，且与肥胖相关，在调节糖代谢中具有一定作用。因此，对网膜素的表达、作用机制及生物学功能的深入研究，有助于进一步阐明肥胖、代谢综合征及糖尿病等的发病机制．从而为这砦疾病的治疗提供新的方向。

Omentin is a novel visceral fat depot-specific adipokine. Current studies have shown that omcntin enhances insulin-stimulated glucose transport and Akt phosphorylation in human subcutaneous as well as visceral adipocytes. It＇s also related to obesity,and play a certain role in the regulation of glucose metabolism. Further study of omentin＇s expression, mechanism and biological functions is benefit for clarifying the pathogenesis of obesity,metabolic syndrome and diabetes, and may provide a new therapeutic direction for these diseases.