表皮生长因子受体在喉癌及癌前病变中的表达

Expression of Epidermal Growth Factor Receptor in Laryngeal Cancer and Its Premalignant Lesions

目的：探讨表皮生长因子受体的表达在喉癌和癌前病变中的作用。方法：应用免疫组化ＡＢＣ法检测喉鳞癌３１例，喉上皮非典型增生１６例，正常喉粘膜１０例的表皮生长因子受体（ＥＧＦＲ）的表达。结果：发现正常喉粘膜组织全部阴性，喉癌的ＥＧＦＲ阳性率为４８％，非典型增生ＥＧＦＲ的阳性率为５６％，并随异型增生程度的增高ＥＧＦＲ表达增加，其差异有显著性（Ｐ＜０．０５）。但ＥＧＦＲ的表达与喉癌发生部位、肿瘤分期、组织分化程度、淋巴结转移、患者生存率之间无显著相关。结论：提示ＥＧＦＲ的表达与喉癌的发生有一定关系，ＥＧＦＲ的过度表达可能为具有高度癌变危险的癌前病变提供早期诊断的辅助指标，但对估计预后的价值有待于进一步研究。

Thirty one cases of laryngeal cancer, 16 cases of atypical epithelial hyperplasia(AEH) and 10 specimens of normal laryngeal mucosa were studied with immunohistochemistry. EGFR was negative in all 10 specimens of normal laryngeal mucosa,compared to 48% positive in laryngeal cancers. The positive expression of AEH was 56% and a relatively higher positive rate was found in severe AEH compared to mild AEH ( P <0.05). There was no statistical correlation between the EGFR status and tumor location, tumor stage,lymph node metastasis,histological grading or survival rate. In conclusion, it is suggested that EGFR might be closely related to the process of carcinogenesis in laryngeal mucosa and that it can be used as an early biomarker identifying premalignant lesions.