类风湿性关节炎患者三种可溶性细胞因子受体水平的临床检测

The clinical significance of determining three soluble serum cytokine receptors in Rheumatoid Arthritis (RA)

目的：为了分析三种可溶性细胞因子受体（ｓＩＬ２Ｒ，ｓＩＬ６Ｒ，ｓＴＮＦＲＩ）对类风湿性关节炎患者的影响。方法：用ＥＬＩＳＡ方法测定了３１例类风湿性关节炎患者血清中三种可溶性细胞因子受体的含量，并与其他指标进行了对比分析。结果：３１例类风湿性关节炎患者的ｓＩＬ２Ｒ、ｓＩＬ６Ｒ和ｓＴＮＦＲＩ的水平显著升高（Ｐ＜００１）。结论：以上三种可溶性细胞因子受体与类风湿性关节炎具有密切的关系，可作为临床监控的指标；测定上述三种可溶性细胞因子受体或许还具有其他特殊意义。

Objective:To analyse the effect of three soluble cytokine receptors(sIL 2R,sIL 6R,sTNFRI) in patients with Rheumatoid Arthritis (RA).Methods:Three soluble cytokine receptors (sCKR)were measured in 31 patients with RA and 32(sIL 2R),24(sIL 6R),25(sTNFRI)donors as normal controls by using ELISA,and other parameters were analysed.Results:Three sCKR levels in patients with RA were much higher than those in normal controls(P<0.01).Conclusion:RA is associated with significant in serum levels of three sCK R.For the clinical monitoring of RA,determination of levels of sIL 2R,sIL 6R and sTNFRI may be particularly useful.