血清前列腺特异性抗原与前列腺增生症关系的探讨

Study of the relationship between serum PSA and BPH

目的 :进一步探讨血清前列腺特异性抗原 ( PSA)与前列腺增生症 ( BPH)之间的关系及PSA在 BPH诊断中的意义。方法 :对有排尿障碍并经病理检查证实的 BPH患者 5 8例进行了分析研究。结果 :72 .41%的患者血清 PSA值 <10 ng/ ml,且各年龄段 PSA值均略高于正常参考范围 ,但与年龄无相关关系 ( P >0 .0 5 )。 44例开放切除术标本每克增生组织产生的 PSA值为 0 .2 1ng/ ml,60 .0 9%的腺体重量 <5 0 g,PSA与腺体重量的增加有一定的正相关关系 ( P <0 .0 5 )。本组病理检查除 BPH外 ,还有 48.82 %患者伴发有癌前病变。结论 :BPH病例血清 PSA值虽略有增高 ,但由于多种因素的干扰 ,PSA失去临床诊断价值。PSA的实际意义在于鉴别和早期发现局限性癌 ,与癌前病变无相关关系。

Purpose:To further study the relationship between serum PSA and BPH as well as the significance of PSA in the diagnosis of BPH.Methods:58 cases of BPH patients with dysurination diagnosed by pathological examination had been analyzed.Results: 72.41 % of all cases PSA<10 ng/ml and a little higher than the normal reference value but had no relation to the age (P> 0.05 ).PSA value per gram of hyperplastic tissue of 44 specimens of open prostatectomy was 0.21 ng/ml. 60.09 % of all the adenoma weight<50 g,and the PAS value had some positive relation with the increasing of adenomatous weight (P< 0.05 ).Other than the cases of only BPH change observed, 48.82 % accompanied with precancerous changes.Conclusions: Althrough there is a little increase of PSA in BPH cases but have no clinical diagnostic value because confused by many factors.The real significance of PSA are to differentiate and eraly diagnose the prostatic cancer.