维持性血透患者长期生存率与血清脂联素的关系

Serum Adiponectin Level and Mortality in Hemodialysis Patients

目的:探讨维持性血透患者长期生存率与血清脂联素的关系。方法:选择血液净化中心规律血液透析超过6个月的患者81例,随访16个月。分析其长期存活率,改良定量SGA评估法评估血透患者营养状况,测定体重指数、血红蛋白、胆固醇、三酰甘油、透析充分性,采用ELISA法测定血清脂联素水平,评估血清脂联素与血透患者长期生存率之间的关系。结果:维持性血透患者1年、2年、3年、5年、10年存活率分别为100%、90.12%、75.31%、38.27%、6.17%。Cox回归模型发现,年龄(r=1.088,P<0.05)、ADPN(r=1.671,P<0.01)是导致患者死亡的危险因素。透析开始年龄≤60岁组生存率高于>60岁组(P<0.05)。结论:血透开始年龄、血清脂联素水平是影响维持性血透患者生存率的危险因素。

Objective：To explore the association of serum adiponectin levels with all-cause mortality in hemodialysis （HD） patients.Methods：We selected 81 hemodialysis patients who survived for more than 6 months after the initiation of HD in our hospital.The patients were measured about body mass index,anemia,lipid,serum ADPN levels and adequacy of hemodialysis and prospectively followed patients for the next 16 months.At the same time,the modified quantitative SGAN was measured to assess the nutrional status in these patients.Serum adiponectin was detected by ELISA.Then correlation analysis between adiponectin and long-term survival was performed.Results：Survival rate of a year,2 years,3 years,5 years and 10 years in maintenance hemodialysis patients was 100%,90.12%,75.31%,38.27% and 6.17% respectively.The Cox regression analysis revealed that age （r=1.088,P0.05） and ADPN （r=1.671,P0.01） became significant determinant of all-cause mortality in hemodialysis patients.Kaplan-Meier analysis revealed that older patients （60 year old） had a significantly lower survival rate compared with those younger patients （≤60 year old） （P0.05）.Conclusion：The results indicated that older age and high ADPN were risk factor of total mortality in hemodialysis patients.