新兵人群A群流行性脑脊髓膜炎抗体的血清流行病学调查

Seroepidemiology study for serogroup A epidemic cerebrospinal meningitis antibody level in the population of recuits

目的了解入伍新兵人群中流行性脑脊髓膜炎（流脑）IgG抗体的流行分布情况，为今后预防提供科学依据。方法采用血清流行病学调查方法，用ELISA法对北京军区近4年来自7个省市的360名入伍新兵的血清进行流脑IgG抗体检测，统计分析其阳性率。结果各年间入伍新兵血清流脑IgG抗体历年无显著变化，阳性率在66．67％～96．67％，平均83．33％；抗体含量在6．23～26．47μg／mL，平均12．42μg／mL，地区间差异有统计学意义，湖北省（96．67％）、山东省（91．43％）和北京市（88．00％）较高，河南省（66．67％）和陕西省（72．50％）较低；入伍前工作与否人群，抗体阳性检出率差异无统计学意义（Х^2=0．12，P〉0．05）。结论入伍新兵人群中流脑IgG抗体阳性率为66．67％-96．67％，抗体含量在6．23—26．47μg／mL，并有地区差异，所以在新兵入伍期间应采取预防接种、健康教育等有效预防措施。

Objective To investigate the distribution of semgroup A epidemic cerehrospinal meningitis antibody IgG in recruits, provide scientific evidence for further prevention and control of the disease. Methods By using EIISA, semgroup A epidemic eerebrospinal meningitis antibody IgG serum samples of 360 recruits, who came from 7 provinces during the past four years, were detected, and the positive rate was analysed. Results There was no statistical difference in serum serogroup A epidemic cerebrospinal meningitis antibody IgG levels in each years, which ranged from 66.67% to 96.67% with a average rate of 83.33%, content of antibody ranged from 6.23 μg/mL to 26.47 μg/mL with an average content of 12.42μg/mL, regional difference existed. The higher level found in recruits from Hubei （96.67%） ,Shandong （91.43%）and Beijing （88.00%）, and lower level from Henan （66.67%） and Shaanxi（72.50%）. There was no significant correlation between the antibody IgG positive rate and education or occupation background of the recruits before their recruitment （Х^2 = 0.12, P 〉 0.05）. Condusions The positive rate of semgroup A epidemic cembrospinal meningitis antibody IgG in recruits range from 66.67% to 96.67%, antibody level range from 6.23 μg/mL to 26.47 μg/mL, with a average content of 12.42μg/mL. The positive rate for antibody IgG varies in different provinces. It is necessary to give vaccination and education for the recruits to prevent serogroup A epidemic cerebmspinal meningitis spreading.