Toll样受体与慢性乙型肝炎的研究进展

Recent advances in research of Toll-like receptors and chronic hepatitis B

Toll样受体（TLRs）是天然免疫应答的主要模式识别受体。近年来的研究表明，一方面HBV通过某种方式抑制了TLRs的表达，从而逃避宿主的免疫清除，造成HBV的持续感染和慢性化；另一方面，TLRs与其相应配体结合后，通过诱导抗病毒细胞因子IFN-α/β、TNF-α等的表达，对机体产生保护性免疫，在抗HBV感染中发挥重要作用。此文就TLRs与慢性乙型肝炎的研究进展进行了综述。

Toil-like receptors （TLRs）are the major pattern recognization receptors of natural immune response. In recent years, studies have shown that HBV inhibits the expression of TLRs to escape from host＇s immune clearance in some way, then resulting in the persistent infection and chronicity of HBV. On the other hand, binding with their corresponding ligands, TLRs provide a protective immunity for our bodies and play a critical role in anti-HBV infection, through inducing the expression of anti-viral cytokine IFN-α/β, TNF-α, etc. The recent advances about TLRs and chronic hepatitis B are reviewed in this article.