HBeAg阴性慢性乙型肝炎患者血清病毒载量与肝组织学改变的关系

Study on the relationship between HBV viral loads and the changes of liver pathological features in patients with HBeAg-negative chronic hepatitis B

目的 探讨HBeAg阴性慢性乙型肝炎患者血清HBV DNA水平与肝组织损害的关系.方法 以HBeAg阳性慢性乙型肝炎病例为对照,回顾分析HBeAg阴性慢性乙型肝炎患者血清HBVDNA水平与肝组织病理炎症分级、纤维化分期之间的关系.结果 HBeAg阴性与阳性组HBV DNA 平均含量分别为（5.38±1.27）log10拷贝/ml和（6.80±1.18）log10拷贝/ml,差异有统计学意义（P〈0.01）.与HBeAg阳性组比较,HBeAg阴性组肝组织炎症分级及纤维化分期较高（P〈0.01）.HBeAg 阴性患者HBV DNA水平与肝组织炎症分级及纤维化分期呈正相关（P〈0.01）.结论 HBeAg阴性慢性乙型肝炎病毒载量低,乙肝病毒载量与肝损害呈正相关.

Objective To investigate the relationship between serum HBV DNA loads and liver histology damage in the patients with HBeAg-negative chronic hepatitis B.Methods The retrospective study was performed.The 514 patients were divided into two groups according to the HBeAg status and the HBeAg positive group was as control.The relationship among HBV DNA loads,live histological inflammation grades and fibrosis stages was analyzed.Results The HBV DNA loads in HBeAg-negative group and HBeAg-positive group were（5.38±1.27）log10 copies/ml and（6.80±1.18）log10 copies/ml respectively（P〈0.001）.The inflammation grades and fibrosis stages of liver tissues in HBeAg-negative group were all significantly higher than those in HBeAg-positive group（P〈0.001）.In HBeAg-negative group,HBV DNA loads displayed a positive correlation with the inflammation grades and fibrosis stages of liver tissues（P〈0.001）.Conclusion In the patients with HBeAg-negative chronic hepatitis B,HBV viral loads are lower than those with HBeAg-positive chronic hepatitis B,and HBV viral loads display a positive correlation with liver the inflammation grades and fibrosis stages of liver tissues.