甲状腺功能低下大鼠血浆激素和脑红细胞膜神经鞘磷脂变化

Changes of serum hormones and brain RBC sphigomyelin in experimental hypothyroidism rats

目的为了了解大鼠实验甲低条件下，血浆激素、脑、红细胞膜神经鞘磷脂的变化。方法应用薄层色谱扫描法，观察了甲基硫脲嘧啶（ＭＴＵ）复制甲状腺功能低下大鼠甲状腺重量、血浆Ｔ３、Ｔ４及脑和红细胞膜神经鞘磷脂（ＳＭ）变化。结果持续用ＭＴＵ组甲状腺重量及脑和红细胞膜ＳＭ明显增加，血浆Ｔ３、Ｔ４水平下降，随着停ＭＴＵ时间不同，其变化不同。结论甲状腺激素不足，可能通过脑。

Objective To study changes of serum hormones and brain and RBC sphingomyelin in experimental hypothyroidism rats.Methods Thyroid weight,serum hormones,brain and RBC sphingomyelins in MTU induced hypothyroidism rat were determined.Results Thyroid weight,brain and RBC sphingomyelins increased significantly and,serum T 3 and T 4 decreased in MTU rats.Change of sphingomyelin in brain and RBC were different after stopping of MTU. Conclusion Hypothyroidism may affect sphingomyelin in brain and RBC,and cause disorder in sturcture and function of nerve system.