两种不同途径溶栓治疗下肢深静脉血栓的疗效比较

Comparison of with two different routes of thrombolytic therapy for deep venous thrombosis

目的探讨不同途径溶栓治疗下肢深静脉血栓的临床效果。方法将下肢深静脉血栓患者126例,根据前瞻性、随机性采用患肢周围静脉溶栓及腘静脉置管溶栓治疗方法进行治疗,并对比治疗效果。结果经外周静脉溶栓治疗组在小腿消肿率为(0.63±0.11)%,大腿消肿率为(0.57±0.09)%,静脉通畅改善度为(32.34±3.77)%,均低于经腘静脉置管溶栓方组的(0.82±0.14)%,(0.89±0.07)%及(55.41±3.21)%(均P<0.05～0.01)。结论经腘静脉顺行置管溶栓治疗下肢深静脉血栓临床治愈率及远期效果明显优于经外周静脉溶栓治疗。

Objective To discuss the clinical effect of two different routes of thrombolysis for the treatment of acute deep vein thrombosis （DVT）.Methods A total of 126 patients with DVT during December 2005 to March 2010 were randomly divided into two groups：（1）transcatheter popliteal vein thrombolysis method （group A）;（2）thrombolysis therapy via peripheral vein （group B）.The venous patency score and patency improvement were observed by venograms or Duplux.Results After treatment,the reduction rate of edema of leg （0.82±0.14）% and of thigh（0.89±0.07）%,and the venous patency improvement rate （55.41±3.21）% in group A were significantly higer than those in thrombol group B（0.63±0.11）%,（0.57±0.09）%and （32.34±3.77）%,respectively （all P0.05-0.01）.Conclusions This results suggest that recovery rate and long term results of transcatheter popliteal vein thrombolysis therapy is better than that of thrombolysis therapy via peripheral vein.