酪氨酸激酶受体B基因多态性与抑郁症的关联性分析

Association analysis between tyrosine kinase receptor B gene polymorphisms and major depressive disorder

目的探讨酪氨酸激酶受体(TrkB)基因多态性与抑郁症的关系。方法收集抑郁症患者(n=237)和正常对照者(n=312)的外周静脉血,提取基因组DNA。采用TaqM an探针SNP基因分型技术检测两组TrkB基因上的两个单核苷酸多态性的基因分型,并分析基因多态性与抑郁症的关系。结果抑郁症组与正常对照组TrkB基因rs1187272和rs993315位点基因型和等位基因分布比较,差异均无统计学意义(P>0.05);rs1187272和rs993315位点基因型联合分析显示,两组比较差异也无统计学意义。结论 TrkB基因rs1187272和rs993315及其构成的单体型与抑郁症无显著关联,TrkB基因的多态性在抑郁症的病因学中可能不起主要作用。

Objective To investigate the relationship between tyrosine kinase receptor B（TrkB） gene polymorphisms and major depressive disorder.MethodsThe samples of peripheral venous blood of 237 patients with major depressive disorder and 312 healthy controls were collected,and DNA was extracted.Two single nucleotide polymorphisms of TrkB gene were genotyped by TaqMan SNP genotyping assays,and the relationship between gene polymorphisms and major depressive disorder was explored.ResultsThere was no significant difference in genotypes and alleles distribution of TrkB rs1187272 and rs993315 between patients with major depressive disorder and healthy controls（P0.05）.The joint analysis of rs1187272 and rs993315 revealed no significant difference between patients with major depressive disorder and healthy controls.ConclusionTrkB rs1187272 and rs993315 and their haplotypes are not significantly related to major depressive disorder,indicating that TrkB gene polymorphisms may not play important roles in the etiology of major depressive disorder.