毒性甲状腺肿合并甲状腺隐性癌

Coexistance of toxic goiter and occult thyroid carcinoma

目的探讨毒性甲状腺肿合并甲状腺隐性癌的临床病理特征及其生物学特性。方法分析１６例毒性甲状腺肿合并甲状腺隐性癌病例的临床及病理资料。结果１６例均为女性，具有典型的毒性甲状腺肿症状和体征，均无气管侵犯和颈部淋巴结转移。癌结节体积与数目不一，以有无包膜及纤维化分型，并对癌组织和细胞的演变趋势进行观察。结论毒性甲状腺肿对隐性癌有阻抑作用，可作为良性病变处理。正常甲状腺组织内如查到砂粒体。

Objective The clinical and pathological characteristics as well as the biologic behaviors of the coexistance of toxic goiter and occult carcinoma were studied.Methods 16 cases of toxic goiter complicated by occult carcinoma were analysed.Results All the cases were female with typical symptoms of toxic goiter.The size and the numbers of the occult cancer lesions varied and they were divided into four types according to the fibrosis and with or without capsule. There was a tendency of regression and degeneration of the cancer lesions and there was no evidence of local infiltration and metastasis.Conclusions The toxic goiter restrains the development of occult cancer lesions,which could be considered and managed as “benign lesions”.The psammoma bodies in the normal thyroid gland usually imply the exisitance of a cancer.