瘤内血管密度与胃癌生物学行为的相关性研究

The study of the relationship between intratumor microvessel density and the biological behavior of gastric carcinoma

目的探讨肿瘤内血管生成与胃癌淋巴结转移及预后的关系。方法采用免疫组织化学ＳＰ法，用抗ＦⅧ因子多克隆抗体对４０例进展期胃癌内的血管进行标记分析。结果淋巴结转移组血管密度（３０±３）显著高于无淋巴结转移组（２０±３）（Ｐ＜００１），瘤内血管密度与胃癌病理分型无关（Ｐ＞００５）、与胃癌术后５年生存率呈明显负相关（Ｐ＜００５）。结论瘤内血管密度与胃癌淋巴结转移密切相关，此法对判断胃癌的预后具有重要的临床意义。

Objective To investigate the relationship between intratumor microvessel density (MD) and lymph node metastasis and prognosis in gastric carcinoma.Methods We studied the MD in 40 advanced progressive gastric carcinoma by immunohistochemical SP method using a polyclonal antibody to FⅧ.Results MD was higher in carcinoma with lymph node involvement (30±3) than that without lymph node involvement (20±3) ( P <0 01).The significantly negtive corelation was found between MD and 5 year survival in postoperative patients with gastric carcinoma ( P <0 05).Conclusions Intratumor MD is strongly related to the metastasis of gastric carcinoma.It may serve as a prognostic factor.