妊高征患者绒毛膜促性腺激素及内皮素变化的临床研究

The changes of serum levels of human chorionic gonadotropin and endothelin in pregnancy induced hypertension.

目的研究血清ｈＣＧ、血浆ＥＴ与妊高征的关系。方法采用放免法测定４５例妊高征孕妇和４８例正常孕晚期妇女血清ｈＣＧ和血浆ＥＴ的值。结果妊高征孕妇血清ｈＣＧ、ＥＴ值明显升高，与正常孕晚期妇女相比差异显著（Ｐ＜００１）。随病情加重其数值进行性升高。血清ｈＣＧ值和血浆ＥＴ值呈正相关（ｒ＝０８１３）。结论ｈＣＧ升高、ＥＴ升高可作为诊断妊高征以及判断病情轻重的指标。说明胎盘缺血、缺氧、滋养叶细胞增生。

Objetive:To study the relationship between the serum level of human chorionic gonadotropin(hCG),endothelin(ET)and pregnancy induced hypertension(PIH).Methods:Serum hCG and ET levels were measured in 45 PIH patients and 48 normal late-stage pregnant women by radioimmunoassay(RIA).Results:Compared with those of normal pregnant women,the serum hCG and ET levels were significantly increased (P<0 01),and the levels increased gradually with clinical development of PIH.A positive correlation was observed between the serum hCG and ET levels(r=0.813).Conclusion:The high levels of serum hCG and ET could be used as an objective diagnostic index of PIH,and coincided with its severity.The ischemia and hypoxia of placenta,hypertrophy of trophoblastic cells and endothelial injury of blood vessels were importat in the pathogenesis and development of PIH. \ \