溃疡性结肠炎患者血清PGE2、PAF水平变化及其临床意义

Changes and clinical significance of serum PGE2 and PAF in ulcerative colitis patients

目的探讨血清前列腺素E2(PGE2)、血小板活化因子(PAF)在溃疡性结肠炎(UC)患者血清中的表达水平变化及临床意义。方法采用酶联免疫吸附试验检测59例活动期和21例缓解期UC患者血清中PGE2、PAF含量变化,并同时进行临床活动指数(CAI)评分的比较。以40例健康体检者作为对照组。结果活动期UC患者血清PGE2、PAF含量均明显高于缓解期组和正常对照组(均P<0.01),缓解期组PGE2、PAF含量与正常对照组比较无明显差异(均P>0.05)。活动期组临床活动指数CAI评分明显高于缓解期组CAI评分(P<0.01)。活动期组患者血PGE2、PAF含量与活动期CAI评分均呈正相关(P<0.01);缓解期组血PGE2、PAF含量与缓解期CAI评分均呈正相关(P<0.05)。结论活动期UC患者血清PGE、PAF水平明显升高,可作为判定UC患者疾病活动的指标,对于判断溃疡性结肠炎病情变化,有一定的临床价值。

Objective To investigate the changes and clinical significance of serum prostaglandin E2（PGE2）,platelet-activating factor（PAF） in patients with ulcerative colitis（UC） patients.Methods ELISA method was used to detect the changes of serum PGE2,PAF in 59 patients with active UC and 21 patients with remissive UC,and at the same time the clinical activity index（CAI） score were compared.Choose 40 healthy subjects as Control group.Results The PGE2,PAF levels in active UC patients were significantly higher than the patients in remission group and control group（P〈0.01）,there is no significant difference in remission group and control group（P〉0.05）.CAI score in activity group were significantly higher than the patients in remission group（P〈0.01）.The serum PGE2,PAF content and CAI score were positively correlated in activity group（P〈0.01）.The serum PGE2,PAF content and CAI score were positively correlated in remission group（P〈0.05）.Conclusion The serum PGE,PAF levels were significantly elevated in activity group,which can be considered as indicators of disease activity in patients with UC,and have some clinical value for judging the changes in condition.