摘要
目的:探讨拉米夫定联合干扰素治疗慢性乙型病毒性肝炎的临床疗效。方法:将60例患者随机分为治疗组和对照组,治疗组给予拉米夫定100mg,每日1次,疗程6个月,联合干扰素治疗,500万IU,肌肉注射,间日1次,疗程12个月;对照组采用拉米夫定治疗,剂量、方法均同治疗组,疗程12个月。观察治疗前后的临床症状和肝功能、HBV-DNA、HBeAg的变化。结果:治疗组肝功能复常率、HBV-DNA和HBeAg阴转率明显高于对照组。两组治疗后比较差异有统计学意义(P<0.05)。结论:拉米夫定联合干扰素治疗慢性乙型病毒性肝炎疗效显著。
Objective：To investigate theclinicaltreatmentefficacyofchronichepatitisB withlamivudinecombinedwithinterferon.Methods：60 patientswereran-domly divided into treatment group and control group.The treatment group received lamivudine 100mg/d of oral for 6 months,combined with 5000000 IU/d of interferon,im,q.o.d for 12 months.The control group received lamivudine 100mg/d of oral for 12 months.Observed the changes of clinical symptoms,liver function,HBV-DNA and HBeAg.Results：The normalization rate of liver function and the negative conversion rate of HBV-DNA and HBeAg of the treatment group were significantly higher.Conclusion：Treatment for chronic hepatitis B with Lamivudine combined with interferon is significant.
出处
《医学信息（中旬刊）》
2010年第8期1985-1986,共2页
Medical Information Operations Sciences Fascicule
关键词
拉米夫定
干扰素
联合治疗
慢性乙型肝炎
Lamivudine
Interferon
Combination therapy
Chronic Hepatitis B
