2Zamecnik PC,Stephenson ML.Inhibition of Rous sarcoma virus replication and cell transformation byaspecificoligode oxynucleotide.Proc Natl Acad Sci,1978,75:280-284.
3Somer W,Heillig M.Antisense oligonucleotides are clinically tested.They inhibit the expression of disease-related genes.Lakartidnin Gen,1999,55(3):348-354.
4Lee MJ,Cho SS,You JR,et al.Intraper itoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model.Gene Ther,2002,9(13):859-866.
5Iversen P.In vivo studies with phosphorothioate oligonucleotides:pharmacokine-tics prolgue.Anticancer Drug Des,1991,6:531-8.
6Agrawal S,Temsamani J,Tang JY.Pharmacokinetics,biodistribution and stability of oligodeoxynucleotide phosphorothioates in mice.Proc Natl Acad Sci U.S.A,1991,88:7595-9.
7Whitesell L,Rosolen A,Neckers LM.In vivo modulation of Nmyc expression by continuous perfusion with an antisense oligonucleotide.Antisense Res Dev,1991,1:343-50.
2Chen W, Zheng R, Baade PD, et al. Cancer statistics in China. CACancer J Clin. 2016;66(2):115-132.
3Guest JF, Panca M, Baeyens JP, et al. Health economic impactof managing patients following a community-based diagnosis ofmalnutrition in the UK. Clin Nutr. 2011;30(4):422-429.
4Philipson TJ, Snider JT, Lakdawalla DN, et al. Impact of oralnutritional supplementation on hospital outcomes. Am J ManagCare. 2013;19(2):121-128.
5Colomer R, Moreno-Nogueira JM, García-Luna PP, et al. N-3 fattyacids, cancer and cachexia: a systematic review of the literature. BrJ Nutr. 2007;97(5):823-831.
6Kubota K, Kuroda J, Yoshida M, et al. Preoperativeoralsupplementation support in patients with esophageal cancer. J NutrHealth Aging. 2014;18(4):437-440.
7Braga M, Wischmeyer PE, Drover J, et al. Clinical evidenceforpharmaconutrition in major elective surgery. JPEN J ParenterEnteral Nutr. 2013;37(5 Suppl):66S-72S.
8Bozzetti F, Forbes A. The ESPEN clinical practice Guidelines on Parenteral Nutrition: present status and perspectives for futureresearch. Clin Nutr. 2009;28(4):359-364.
9Yoshikawa T, Hiki N, Taguri M, et al. A phase III trial to evaluatethe effect of perioperative nutrition enriched with eicosapentaenoicacid on body weight loss after total gastrectomy for T2-T4a gastriccancer. Jpn J Clin Oncol. 2012;42(5):459-462.
10Yan der Meij BS, van Bokhorst-de van der Schueren MA, LangiusJA, et al. n-3 PUFAs in cancer, surgery, and critical care: a systematicreview on clinical effects, incorporation, and washoutof oral or enteralcompared with parenteral supplementation. Am JClin Nutr. 2011;94(5):1248-126.