迷走神经切断后对肠系膜淋巴管动力影响的实验研究

The experimental study of the effects of vagotomy on the dynamics of mesenteric lymphatic vessel in rat

目的：观察迷走神经切断前后淋巴管的动力学变化，探讨神经－淋巴管－胃肠道功能之间的关系。方法：用显微录相技术观察Ｗｉｓｔａｒ大鼠肠系膜淋巴管。结果：迷走神经切断后淋巴管自主收缩频率（ａ）、静态口径（ｄ）、总收缩活性指数（ＩｎｄｅｘⅡ）均显著降低（Ｐ＜０．０５），淋巴管的舒缩节律及瓣膜的关启亦不规整，二者之间失去了同步性。结论：迷走神经可调节淋巴管收缩的发动、传播，维持淋巴循环，促进淋巴形成。

Objective:To study the dynamic changes of lymphatic vessels responsed to vagotomy and to investigate the functional relations among nerve,lymphatic vessel and gastrointestinal tract.Methods:The mesenteric lymphatics in Wistar rat were observed under vital microscope with TV recorder.Results:After denervation,the lymphatic contraction frequency (A),the lymphatic diameter in static state (d) and overall lymphatic contractile activity (index Ⅱ) decreased significantly (P<0.05).The rhythm of lymphatic contraction,and the open and close of valves became irregular and inconsistent with each other.Conclusions:The vagus could modulate the starting,spreading of the lymphatic contraction,sustain lymph circulation,enhance the lymph formation and promote the gastrointestinal function.