摘要
目的:观察乌梅丸治疗溃疡性结肠炎的效果及探讨乌梅丸对溃疡性结肠炎患者的细胞因子的影响。方法:将60例溃疡性结肠炎患者随机分成治疗组、对照组。分别口服乌梅丸免煎剂、柳氮磺胺吡啶片治疗。观察临床疗效,并检测治疗前后患者血清TNF-a、IL-6及IL-8的含量。结果:治疗组疗效明显优于西药对照组(P<0.05),治疗组更能显著降低溃疡性结肠炎患者血清TNF-a、IL-6及IL-8水平。结论:乌梅丸治疗溃疡性结肠炎疗效显著,可能通过调节溃疡性结肠炎患者细胞因子而达到治疗作用。
Objective：To investigate the effectsofBlack PlumPillon TNF-a,IL-6 and IL-8 inpatientswith ulcerativecolitis（UC） and itstherapeuticeffect.Methods：60 patients with UC were divided into therapy group（30 patients treated with Black Plum Pill） and control group（30 patients treated with Sulfasalazine）.TNF-a,IL-6 and IL-8 in serum were detected by ELISA in all patients before and after treatment.Results：Creative effects in therapy group was obviously better than in control group,the difference was significance（P 0.05）.After treatment,Compared with control group,therapy group had the lower plasma levels of TNF-a,IL-6 and IL-8（P 0.05）.Conclusions：Black Plum Pill is effective for patients with UC,down regulation of the expression of TNF-a,IL-6 and IL-8 in serum may be one of it＇smechanism.
出处
《医学信息（中旬刊）》
2010年第8期2188-2189,共2页
Medical Information Operations Sciences Fascicule
基金
广东省中医药管理局
