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弥漫性大B细胞淋巴瘤中Bcl-2基因重排与蛋白表达的关系探讨

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摘要 目的探讨Bcl-2在弥漫性大B细胞淋巴瘤(diffuse large B—cell lymphoma,DLBCL)不同类型中的表达及意义。方法应用免疫组织化学S—P法检测60例弥漫性大B细胞淋巴瘤标本中Bcl-2蛋白的表达水平;同时行RT—PCR检测外周血Bcl-2/IgH的表达水平。结果60例DLBCL中,Bcl-2阳性率分别为61.67%(37/60);Bcl-2/IgH的阳性表达12例(12/60)。结论Bcl-2有望成为DLBCL亚分类的指标。
出处 《实用肿瘤学杂志》 CAS 2010年第3期260-263,共4页 Practical Oncology Journal
基金 云南省教育厅科学研究基金项目(NO.07C10461)
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  • 1Yuan R,Br J Cancer,1993年,67卷,922页
  • 2Ponzoni M,Arrigoni G,Gould VE,et al. Lack of CD29 (beta 1 integrin) and CD54 (ICAM- 1 ) adhesion molecules in intravascular lymphomatosis [ J ]. Hun Pathol,2000,31: 220 - 6.
  • 3Carbone A, Gloghini A, Cozzi MR,et al. Expression of MUM1/IRF4 selectively cluters with primary effusion lymphoma among lymphomatous effusions. Implications for disease histogenesis and pathogenesis [ J ]. Br J Haematol,2000,111:247 - 57.
  • 4O'Donovan M,Silva I,Uhlmann V,et al. Expression profile of human herpevirus ( HHV8 ) in pyothorax associated lymphoma and in effusion lymphoma [ J ]. Mod Pathol,2001,54: 80 - 5.
  • 5Nakatsuka S, Nishiu M, Tomita Y, et al. Enhanced expression of neuron-specific enolase (NSE) in pyothorax - associated lymphoma (PAL) [J]. Jpn J Cancer Res,2002,93:411 -6.
  • 6Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. World Health Organization classification of tumours. Pathology and genetics,tumours of haematopoietic and lymphoid tissues[M]. Lyon: IARC Press,2001:171 -87.
  • 7Feller AG, Diebold J. Histopathology of nodal and extranodal nonHodgkin's lymphomas [ M ]. Berlin: Springer-Verlag, 2004: 75 -99.
  • 8Ramsay AD,Smith WJ, Isaacson PG. T-cell-rich B-cell lymphoma [ J ]. Am J Surg Pathol, 1998,12: 433 - 43.
  • 9Delabie J, Vandenberghe E, Kennes C, et al. Histiocyte-rich Bcell lymphoma. A distinct clinicopathologic entity possibly related to lymphocyte predominant Hodgkin's disease, paragranuloma subtype[J]. Am J Surg Pathol,1992,16:37 -48.
  • 10Haralambieva E, Pulford KA, Lamant L,et al. Anaplastic large-cell lymphoma of B-cell phenotype are anaplastic lymphoma kinase (ALK) negative and belong to the spectrum of diffuse large B-cell lymphomas[ J]. Br J Haematol,2000,109: 584 - 91.

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