基于功效和物质基础的香加皮毒性研究进展

Research Development on Toxicity of Cortex Periplocae Related to Efficacy and Chemical Material Basis

目的为进行功效和毒性导向下的化学成分分离、控制和功效与毒性成分的"量效关系"和"量毒关系"研究提供文献依据和研究思路。方法对香加皮近十几年来国内和国外相关文献进行整理、分析与归纳。结果目前,香加皮针对功效、物质基础和毒性的研究主要停留在其所含有的强心苷类化合物基础上,对香加皮的药理毒理研究还很不够深入,关于香加皮中是否含有其它功效和毒性物质基础很少有所报道。结论只有在香加皮功效表达和功效物质基础分离与控制的过程中,进行毒性的研究和毒性物质基础的安全控制,才能提出切合香加皮临床使用过程中预防药品不良反应的预警方案和早期诊疗措施,确保香加皮临床用药安全。

Objective To provide literature evidences asis and research ideas of efficacy and toxicity of the chemical composition of guided separation、control and efficacy,and the research on the ＂dose-effect relationship＂ and ＂dosetoxicity relationship＂about the toxicial components.Methods References in the last decades both at home and abroad about Cortex Periplocae were collated,analyzed and summarized.Results At present,Cortex Periplocae for efficacy,and toxicity of the material basis of the study to stay contained on the basis of cardiac glycosides,The pharmacology and toxicology studies on the Cortex Periplocae not enough depth,whether on the Cortex Periplocae contain other material basis for efficacy and toxicity has been reported rarely.Conclusion The research on Cortex Periplocae about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression,so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction、the early diagnosis and treatment measures that can be referred to clinical usage.Cortex Periplocae will be ensured to use safety as a clinical drug.