^(131)I治疗分化型甲状腺癌患者唾液腺损伤的影响

Damage of salivary gland function induced by ^(131)I treatment in patients with differentiated thyroid carcinoma

目的:了解分化型甲状腺癌(differentiated thyroid carcinoma,DTC)的患者经大剂量131I治疗后,慢性唾液腺损伤的发病情况。方法:143例分化型甲状腺癌的患者经手术切除后行大剂量的131I治疗,在131I治疗前和治疗后的6～39个月随访中分别行唾液腺功能显像。结果:143例DTC患者中有31例(21.7%)出现慢性唾液腺损伤,131I治疗2次以上(累积剂量7.4～37.0GBq)发生慢性唾液腺损伤的发病率明显高于131I治疗1次者(累积剂量<3.7GBq)(P<0.005)。结论:反复的、大剂量131I治疗引起的慢性唾液腺损伤更多见。

Objective：To investigate the chronic function damage of the salivary gland by high dose of 131I in the treatment of differentiated thyroid carcinoma（DTC）.Methods：Salivary gland scintigraphy,for function evaluation,were made before and 6～39 months after high dose of 131I treatment on 143 patients with DTC after thyroid ablation.Results：21.7%（31/143）patients with DTC suffered from chronic salivary gland damage after 131I treatment.And the incidence of chromic damage was more predominant in patients received repeated 131I therapy（aggregated dose ranging from 7.4～37.0 GBq）than those treated with once 131I therapy（dose less than 3.7 GBq）.（P0.005）.Conclusion：Repeating and large dose of 131I treatment is more common in the causes of chronic salivary gland damage.