后路同种异体骨治疗胸腰椎爆裂性骨折的前瞻性研究

Application of allograft bone for posterior spinal fusion in thoracolumbar fracture

目的:探讨同种异体骨移植在胸腰椎爆裂性骨折后路融合术中的使用效果。方法:对33例胸腰椎爆裂性骨折患者行同种异体骨或自体骨移植后路融合术,男21例,女12例,随机分为单纯使用同种异体骨移植组(16例)和采用自体髂骨移植(17例)。术后对两组患者的平均手术时间、出血量和并发症进行对比分析,术后24周时比较两组患者的融合率,采用Oswestry评分对两组患者进行功能评价。结果:与自体骨移植组相比,同种异体骨移植组手术时间明显缩短,失血量也明显减少。术后24周两组融合率均达到100%,Oswestry评分均无显著性差异。结论:在胸腰椎爆裂性骨折后路融合术中,同种异体骨移植可以取得满意的临床效果。

Objective：To investigate the efficacy of allograft bone in posterior spinal fusion in thoracolumbar fracture.Methods：33 patients with thoracolumbar fracture,who underwent posterior spinal instrumentation and fusion using allograft or autograft bone,were evaluated prospectively.All of the patients were randomized into group A（16 cases using only allograft bone）and group B（17 cases using only autograft iliac bone）.The mean operative duration,average blood loss and complications between the two groups were analyzed comparatively.Fusion rate and Oswestry score at 24 weeks after surgery of the 2 groups were calculated respectively.Results：Group A was better than group B by a shorter operative duration,less blood loss.Fusion rate at 24 weeks after surgery of the two groups was 100%.There was no significant difference of Oswestry score at 24 weeks after surgery between the 2 groups.Conclusion：A satisfactory outcome can be achieved in posterior spinal fusion in thoracolumbar fracture using allograft bone.