CD58/CD2表达与宫颈癌肿瘤生物学的关系及意义

The significance and relationship between the expression of CD58 / CD2 and oncobiology characteristic of uterine cervix cancer

目的:探讨CD58/CD2在宫颈癌患者的表达水平及其与临床病理特征的关系。方法:分别应用免疫组织化学技术及流式细胞术检测40例宫颈癌患者及30例CIN患者组织CD58水平和外周血CD2+细胞百分率,以30例子宫肌瘤患者作为正常对照。结果:宫颈癌患者外周血CD2+细胞百分率及癌组织CD58表达水平均明显低于CIN组及正常对照组,差异均具有统计学意义(P<0.05),且不同病理分级、肿瘤直径及间质浸润深度宫颈癌患者CD2+细胞百分率和CD58表达水平分别比较,差异均具有统计学意义(P<0.05),而不同临床分期、年龄及绝经与否宫颈癌患者CD2+细胞百分率和CD58表达水平分别比较,差异均无统计学意义(P>0.05)。结论:CD58/CD2的表达与宫颈癌的发生、发展有关,二者可作为治疗及评价预后的参考指标,并可为肿瘤靶向治疗提供新靶点。

Objective：To explore the expression level of CD58/CD2 and its relationship with the clinical pathological characteristics. Methods：Among 40 patients with uterine cervix cancer and 30 CIN patients,immunohistochemistry method was used to detect the expression of CD58,and flow cytometry was used to detect the CD2 expression in peripheral blood cells,and 30 cases of hysteromyoma were collected as normal controls. Results：The expressions of CD2 and CD58 in patients with uterine cervix cancer were significantly lower than those in CIN patients and normal controls,respectively （P 0.05）. The expression levels of CD58/CD2 were different in uterine cervix cancer patients with different pathological grades,tumor size and invasion depth （P 0.05）. But there were no significant differences in uterine cervix cancer patients with different FIGO stage,age and menopause situation respectively（P 0.05）. Conclusion： The expressions of CD58 / CD2 were correlated with the development of uterine cervix cancer,and they could be used as the index for evaluating treatment efficacy and prognosis,and may be the new targes for therapy.