江苏省男性HIV感染者/艾滋病人中解脲脲原体和生殖支原体的检测分析

Detection of Ureaplasma urealyticum and Mycoplasma genitalium in male HIV / AIDS population in Jiangsu Province

目的:调查江苏省男性HIV感染者/艾滋病人解脲脲原体(Ureaplasma urealyticum,Uu)和生殖支原体(Mycoplasma genitalium,Mg)的感染情况,为进一步的研究和分析其与艾滋病进程之间的关系提供基本信息。方法:采集调查对象的首段尿液,Uu检测采用培养鉴定法,Mg检测采用巢式PCR技术。结果:江苏省男性HIV+/AIDS患者中Uu和Mg的检出率分别为51.71%和28.97%;不同地区患者的支原体感染情况存在差异;HIV+/AIDS患者外周血CD4+细胞计数越低,Mg感染率越高,二者之间的负关联具有统计学意义。结论:江苏省男性HIV+/AIDS患者中存在较高的Uu和Mg的感染状况;Mg感染与机体的免疫状况可能相关。

Objective：To examine the prevalence of Ureaplasma urealyticum and Mycoplasma genitalium in male HIV/AIDS patients in Jiangsu Province,in order to provide evidence for future researches on the role of these two mycoplasmas in AIDS. Methods：The organisms were detected from first-void urine specimens in males. Ureaplasma urealyticum was detected by culture method,whereas nested-PCR was used to detect Mycoplasma genitalium. Results：The prevalences of Ureaplasma urealyticum and Mycoplasma genitalium in male HIV / AIDS patients in Jiangsu Province were 51.71% and 28.97%,respectively;the rates of different areas were various. The association of Mycoplasma genitalium infection with the CD4＋ cell counts in HIV / AIDS patients was significant. Conclusion：The prevalences of Ureaplasma urealyticum and Mycoplasma genitalium in male HIV / AIDS patients in Jiangsu Province were both high, and Mycoplasma genitalium infection may connect with people’s immune status.