VEGF-D及Ki-67在乳腺癌淋巴结转移中的作用

The significance of VEGF-D/Ki-67 expression in breast cancer lymph vessel metastasis.

目的探讨VEGF-D及Ki-67在乳腺癌淋巴结转移中的作用和意义。方法采用免疫组化二步法检测90例乳腺癌组织中VEGF-D和Ki-67的表达。结果①VEGF-D阳性率在淋巴结转移组为82%(41/50),显著高于未转移淋巴组37.5%(15/40),(P<0.01)。Ki-67阳性率在淋巴结转移组为84%(42/50),显著高于未转移淋巴组42.5%(17/40),(P<0.05),且VEGF-D与Ki-67的表达显著相关(P<0.05);②VEGF-D的表达与年龄、肿瘤大小、病理分型、临床分级、ER、PR无关,与CerbB-2表达显著相关(P<0.05)。Ki-67的表达与年龄、肿瘤大小无相关性(P>0.05),而与肿瘤组织分级、淋巴结转移有显著相关性(P<0.05)。结论 VEGF-D和Ki-67的表达与乳腺癌淋巴结转移有关,可能促进了乳腺癌淋巴管的生成和增殖。

Objective To study the effects and significance of VEGF-D/Ki-67 expression in breast cancer lymph vessel metastasis.Methods Two-stcps immunobistochemiscal staining was used to detect the expression of VEGF-D/Ki-67 in 90 cases of breast cancer.Results ①The positive rate of VEGF-D,82%（41/50）in lymph node metastasis group,was significantly higher than that,37.5%（15/40）,in no lymph node metastsis group（P0.01）.The positive rate of Ki-67,84%（42/50）,in lymph node metastasis group,was significantly higher than that,42.5%（17/40）.in no lymph node metastsis group（P0.05）,and significant correlation was found between the expression of VEGF-D and Ki-67（P0.05）;②There was no correlation between the expression of VEGF-D and age,tumor size,pathology,grade,ER and PR.but significant correlation with CerbB-2（P0.05）.There was no correlation between the expression of Ki-67 and age,tumor size（P0.05）,but there was relation between the expression of Ki-67 and pathology,grade,lymph node metastsis（P0.05）.Conclusion The expression of VEGF-D and Ki-67 is significantly correlated with breast cancer lymph vessel metastasis and maybe promote lymphangiogenesis of breast cancer.