血清癌抗原125与肝硬化患者肝功能损害的相关性研究

The research of correlation of cancer antigen 125 in serum and the impairment of hepatic function in patients with hepatic cirrhosis.

目的研究血清癌抗原125(cancer antigen 125,CA125)和肝硬化患者肝功能损害的相关性。方法应用化学发光法测定79例肝硬化患者和58例正常体检者血清CA125的浓度。按照Child-Pugh分级标准将所有患者分为Child-Pugh A级、B级、C级三组。根据有无腹水将所有患者分为有腹水、无腹水二组。结果正常体检者血清CA125浓度为(18.12±11.45)U/ml,肝硬化患者血清CA125浓度为(337.95±193.98)U/ml,二者差异有统计学意义(P<0.001)。79例肝硬化患者中Child-Pugh A级23例、B级37例、C级19例,Child-Pugh评分分别为(3.57±1.59)、(8.35±0.86)、(10.89±1.05),血清CA125浓度分别为(148.65±89.59)、(324.84±105.85)、(592.63±127.38)U/ml。其中有腹水者41例,无腹水者38例,Child-Pugh评分分别为(9.88±1.89)、(5.08±2.28),血清CA125浓度分别为(491.07±132.55)U/ml、(172.74±79.46)U/ml。Child-Pugh B级患者血清CA125浓度较A级显著升高(P<0.001),C级患者血清CA125浓度较B级显著升高(P<0.001)。有腹水者血清CA125浓度较无腹水者显著升高(P<0.001)。肝硬化组患者血清CA125浓度升高与肝硬化Child-Pugh分级相关(r=0.841,P<0.01)。结论血清CA125与肝硬化患者肝功能损害程度相关,可作为反映肝功能损害程度的指标之一。

Objective To investigate the correlation of CA125 in serum and the impairment of hepatic function in patients with hepatic cirrhosis.Methods The levels of CA125 in serum were observed in 79 patients with hepatic cirrhosis and 58 persons without any disease.All patients were divided into 3 subgroups according to Child-Pugh＇s classification： Child-Pugh A,B and C.And all patients were divided into 2 subgroups according to wether suffered from ascites.Results The levels of CA125 in serum of persons without any disease was（18.12±11.45）U/ml,and the levels of CA125 in serum of patients with hepatic cirrhosis was（337.95±193.98）U/ml,there was statistical significance in the distinction（P0.001）.There were 23,37 and 19 cases in Child-Pugh A,B and C grade subgroups,respectively.And the Child-Pugh＇s score was（3.57±1.59）,（8.35±0.86）and（10.89±1.05）,and the values of CA125 in serum was（148.65±89.59）,（324.84±105.85） and（592.63±127.38）U/ml,correspondingly.There were 41 and 38 cases in the ascites and non-ascites subgroups,respectively.And the Child-Pugh＇s score was（9.88±1.89）and（5.08±2.28） and the values of CA125 in serum was（491.07±132.55）U/ml and（172.74±79.46）U/ml,correspondingly.The values of CA125 in serum in group B was more significant than group A（P0.001）.The values of CA125 in serum in group C was more significant than group B（P0.001）.The values of CA125in serum of patients with ascites was more significant than patients without ascites（P0.001）.There was a correlation between the values of CA125 in serum and the Child-Pugh＇s score（r=0.841,P0.01） in patients with hepatic cirrhosis.Conclusion The levels of CA125 in serum can implicate the impairment of hepatic function and can be a marker for impairment of hepatic function.