复方木尼孜其颗粒治疗黄褐斑临床疗效及机制研究

Study on clinical effects and neurogenic mechanism of the Compound muniziqi granules in patients with chloasma.

目的探讨复方木尼孜其颗粒治疗黄褐斑临床疗效及其机制。方法将103例黄褐斑患者随机分为两组,试验组53例口服复方木尼孜其颗粒,6g/次,3次/d;对照组50例口服维生素C,0.2g/次,3次/d,并口服维生素E,0.1g/次,3次/d;两组均为4周1个疗程,共治疗2个疗程观察疗效。103例患者治疗前后血清与正常对照组血清采用放射免疫法检测血清雌激素(E2、FSH、LH)水平。结果疗程结束后治疗组和对照组相比较,有效率分别为73.58%和42.00%。两组治疗前血清E2、FSH及LH较健康对照组明显升高(P<0.05),治疗组于治疗后血清E2及LH水平显著降低(P<0.05),FSH差异无统计学意义(P>0.05);对照组治疗前后各项指标差异无统计学意义(P>0.05)。结论复方木尼孜其颗粒治疗黄褐斑的作用机制可能与调节内分泌而影响雌激素水平有关。

Objective To investigate the clinical efficacy and mechanisms of Compound muniziqi granules in treatment of chloasma.Methods 103 chloasma patients were randomly divided into two groups： 53 cases in experimental group,who take Compound muniziqi granules of 6g each time and 3 times per day;50 cases in control group,who take vitamin C of 0.1g each time and 3 times per day as well as vitamin E of 0.1g each time and 3 times per day.The period of treatment in each group last four weeks and the patients are treated for totally two periods,then the treatment effect are observed.Serum estrogen（E2,FSH,LH） levels of the 103 patients＇serum before and after treatment and the control group＇s serum are tested by radioimmunoassay.Results After finishing the treatment,a comparison is made between experimental group and control group.The effective rates of two groups were separately 73.58% and 42.00%.The patients＇serum level of E2,FSH and LH in the two groups before treatment was signifcantly higher than the healthy control group（P0.05）,the treatment group after treatment of serum E2 and LH levels were significantly lower（P0.05）,while there is no significant difference in FSH（P0.05）;in control group,there was no significant difference between the indicators before and after treatment（P0.05）.Conclusion Mechanisms of Compound muniziqi granules in treatment of chloasma may be related with the regulation of endocrine,which consequently influences the level of estrogen.