摘要
目的探讨脑心通对老龄大鼠慢性脑缺血后行为学障碍的影响。方法用水迷宫法分别测试慢性脑缺血、高血脂症及给予步长脑心通干预后老龄鼠的学习记忆功能情况。结果高血脂症老龄鼠脑缺血后在水迷宫找到平台的时间明显延长,经过的路程明显增加,与非高血脂症脑缺血组比较有显著性差异(P<0.05);给予脑心通胶囊8周后各指标改善明显。结论脑心通能预防和改善血管性痴呆,其作用可能与降脂作用对脑缺血时神经元-血管单元的多重保护相关。
Objective It is to investigate the influence of Buchang Naoxintong on behavior impairment in elder rats with chronic cerebral ischemia.Methods The Learning and memory ability of elder rats with chronic cerebral ischemia,hyperlipemia and treated by Buchang Naoxintong was tested by water maze.Results The learning and memory ability of the elder rats with hyperlipemia was decreased after cerebral ischemia,there was significant difference to compared with no hyperlipemia（P0.05）.Following treatment of Buchang Naoxintong 8 weeks,these indexes were significant improved.Conclusion Buchang Naoxintong can prevent and treat vascular dementia,the effect may be related to the neurovascular unit protection in cerebral ischemia.
出处
《现代中西医结合杂志》
CAS
2010年第21期2623-2624,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省中医药管理局科研课题(2007216)
广州市卫生局中医药中西医结合科研课题(2007A03)
关键词
血管性痴呆
步长脑心通
行为学障碍
vascular dementia
Buchang Naoxintong
behavior impairment
