高效毛细管电泳法研究阿托品类药物的手性分离

Study on the enantiomeric separation of atropines by high performance capillary electrophoresis

目的：对阿托品、东莨菪碱和樟柳碱等药物对映体的手性分离进行研究。方法：用高效毛细管电泳法（ＨＰＣＥ），分别以β环糊精（βＣＤ）和羧甲基β环糊精（ＣＭβＣＤ）为手性选择剂。结果：ＣＭβＣＤ可使阿托品和东莨菪碱的对映体得到部分分离，使樟柳碱的对映体得到完全分离；βＣＤ未能拆分阿托品和东莨菪碱的对映体，仅使樟柳碱的对映体得到部分分离。

OBJECTIVE:Study for the chiral separation of the racemic atropine,scopolamine and anisodine.METHODS:High performance capillary electrophoresis(HPCE) had been used for the chiral separation with β cyclodextrin(β CD) and 2,6 di Ocarboxymethyl β cyclodextrin(CM β CD) as the chiral selectors employing bare fused silica capillary.RESULTS:β CD could not give enantiomeric resolution for atropin and scopolamine.CM β CD gave a baseline chiral separation for anisodine and partial chiral separation for atropin and scopolamine.CONCLUSIONS:CM β CD has stronger recognition than that of β CD for the chiral separation of the basic drugs under study.