药物偶联亲和高分子微球对牛血蛋白吸附性能研究

Adsorption of BSA Protein onto Affinity Polyer Latex Microsphere Drug

在制备亲和高分子乳液微球基础上,对其进行空间臂改性和药物分子偶联制得PSGN-MTA亲和高分子微球药物。为研究亲和高分子微球生物相容性,考察了高分子微球药物在缓冲液中药物释放行为及对BSA蛋白吸附能力。结果表明,亲和微球表面化学键合MTA药物浓度较高且分布均匀时,对BSA蛋白的吸附过程较符合一级动力学方程。还考察了pH值对BSA蛋白吸附的影响,中性条件时PSGN-MTA微球对于BSA吸附效果较好。

The surface modified polymer latex microsphere was immobilized with pemetrexed disodium （MTA） to prepare the affinity polymer latex microsphere drug. The propeties of durg release from mierospheres in phosphate buffer and the adsorption of BSA protein on the polymer latex mierosphere drug were emphatically studied. The result showed that the higher covalent immobilization concentration and uniform distribution of MTA on the polymer mierospheres, the better adsorption result of BSA protein. The process of BSA protein adsorption onto polymer latex microsphere drug accords with the first order kinetics under ideal condition. The adsorption of BSA protein on polymer microsphere drug will be suitable in neutral pH solution systerm.