长效避孕针醋酸甲羟孕酮引入性试验

An Introductory Clinical Trial of Three Monthly Injectable Contraceptive Depot Medroxyprogesterone Acetate

目的评价醋酸甲羟孕酮避孕针在中国妇女中常规使用时的避孕有效率、续用率、副反应和可接受程度。方法本研究为一开放临床随访试验，１９８５例自愿使用避孕针的妇女每３个月接受１次注射，随访１年。结果１９８５例共使用醋酸甲羟孕酮２０７７２妇女月（１７３１７妇女年），１年累积续用率为７４％。避孕失败３例，生命表法１年累积失败率为０２％。其他原因的１年累积停用率为闭经（４８％）、与出血有关的问题（１３４％）、其他医学理由（２６％）、其他个人理由（２１％）和失访（１６％）。主诉主要是不规则出血、闭经、经期延长。哺乳妇女的主诉发生率明显低于非哺乳妇女。结论醋酸甲羟孕酮为一高效的长效避孕针，在良好咨询及随访前提下，只要使用得当，在中国妇女中可有良好的可接受性。

Objective To evaluate contraceptive efficacy, continuative rate of use, side effects and acceptability of depot medroxyprogesterone acetate (DMPA) injectable contraception preparation in Chinese women. Method This was an open study. One thousand nine hundred and eighty five women acquiring contraception received DMPA injection after obtaining informed consent and were followed up every 3 month up to one year. Results The total experience accumulated was 1 731.7 women year with DMPA for 1 985 users. The one year continuation rate was 77.4%. Three subjects became pregnant, the one year accumulative life table failure rate was 0.2%. The accumulative discontinuation rates at one year for other reasons were amenorrhoea (4.8%), bleeding related (13.4%), other medical reasons (2.6%), other personal reasons (2.1%) and lost to follow up (1.6%). The main complaints were irregular bleeding, amenorrhoea and prolonged bleeding. Lactating women had significantly lower rate of complaint. Conclusion DMPA is a highly effective long acting contraceptive, it could have good acceptability, especially for lactating women, under the well consultation.