牛磺酸对柯萨奇B3病毒感染新生大鼠心肌细胞外向钾电流的影响

Effects of Taurine on Outward K + Current in Neonatal Rat Cardiomyocytes Infected with Coxsackievirus B3

观察牛磺酸对柯萨奇Ｂ３病毒（ＣｏｘｓａｃｋｉｅｖｉｒｕｓＢ３，ＣＶＢ３）感染新生大鼠心肌细胞外向钾电流（ｏｕｔｗａｒｄｃｕｒｒｅｎｔ，Ｉｏｕｔ）的影响。方法运用全细胞膜片钳技术记录了分离的大鼠心肌细胞外向钾电流，并观察牛磺酸的作用。结果ＣＶＢ３感染可使正常大鼠心肌细胞Ｉｏｕｔ明显增加，牛磺酸对正常大鼠心肌细胞Ｉｏｕｔ无明显影响，但可使ＣＶＢ３感染的Ｉｏｕｔ趋于正常。结论牛磺酸对ＣＶＢ３感染心肌细胞Ｋ＋通道电流的作用可能是其发挥抗心肌损伤作用的机制之一。

Purpose To investigate the effect of taurine on outward K + current ( I out ) in neonatal rat cardiomyocytes infected with Coxsackievirus B3 (CVB3).〖WT10.HZ] Methods Using whole cell patch clamp technique, I out was recordered in isolated neonatal rat cardiomyocytes.〖WT10.HZ] Results CVB3 infection increased I out ,taurine had no obvious effect on I out in normal cardiomyocytes,but normalize it in cardiomyocytes infected with CVB3.〖WT10.HZ] Conclusions The effect of taurine on outward K + current in rat cardiomyocytes infected with CVB3 may be one of the mechanisms by which taurine protects cardiomyocytes from damage. 〖WT10.HZ]