α-catenin在膀胱移行细胞癌中的表达及其临床意义

Expression of α-catenin in transitional cell carcinoma or bladder and its clinical implication

目的探讨α-Catenin在膀胱癌中的表达及其与膀胱癌生物学行为之间的关系。方法应用免疫组化SP法检测α-Catenin在35例膀胱癌和10例正常膀胱中的表达，结果10例正常膀胱均为阳性，阳性着色位于相邻上皮细胞的边缘．胞浆内无表达。α-Catenin的异常表达率为19/35（54.3%），其中G1为3/12（25％）；G2为7/13（53.9%);G3为9/10（90%）。TA～T1为5/13（38.5%）；T2～T3为10／11（90.9%）、不同的分期分级间均有显著性差异。4例术后一年内死亡的患者α-Catenin表达均为阴性，与存活期超过一年者相比亦有显著性差异.结论α-Catenin的低表达可能在膀胱癌的进展中起着重要作用；检测其表达对膀胱癌的诊断和预后有一定临床意义。

Objective To detect tile edpression of α-catenin in transitional cell carcinoma of bladder and its correlation with the behavior of bladder cancer. Method The immunohistochemical staining with strespvidin peroxidase conjugated method (S-P method) was conducted to determine the expression of α-catenin in 35 cases of bladder cancer and 10 cases of normal bladder tissues. Result: α-Catenin was uniformly positive in 10 cases of normal bladder tissues, and abnorma expression was observed in 3/ 12 (25%) ) of G1. 7/13 (53. 9 % ) of G2 and 9/10(90% ) of G3 tumors; 5/13(38.5 % ) of T(A-1) tumors, 10/11 (90. 9 % ) of T(2-3) tumors respectively. There was a statistica significance between G1 and G3 , or G2 and G3 , or T(A-1),T(2-3). All 4 cases, coho died in one year, were negative α-Catenin expression . Conclusion Down regulation of α-catenin was commonly occurred in bladder cancers and correlated with tumor grade and stage . Down regulation of α-catenin might play an important role in the progression of transitional cell carcinoma of bladder.