中国淡水鱼油制剂治疗高血脂症患者的疗效观察

Effect of Chinese fresh water fish oil on hyperlipidemia

目的 :为探讨淡水鱼油对高血脂症患者血脂和前列腺素代谢的影响。方法 :采用随机、双盲、平行试验方法 ,将 90例高血脂症患者分两组进行观察 , 组 (治疗组 ) 4 6例 ,给予淡水鱼油乳化剂10～ 15 ml tid, 组 (对照组 ) 4 4例 ,给予 Vit E 15 0 mg/ d,均服药 4～ 8周 ,服药前及服药后 4～ 8周测定血总胆固醇 ( TC)、甘油三酯 ( TG)、高密度脂蛋白胆固醇 ( HDL- C)、低密度脂蛋白胆固醇 ( LDL-C)、载脂蛋白 AI、B( apo AI、B)、脂蛋白 ( a)〔 L p( a)〕、血栓素 B2 ( Tx B2 )、6-酮 -前列腺素 F1α( 6-酮 -PGF1α)以及血浆和红细胞二十碳五烯酸 ( EPA)、二十二碳六烯酸 ( DHA)。结果 : 组 EPA、DHA、6-酮 - PGF1α显著升高 (均 P<0 .0 1) ,Lp( a)、TC、TG和 L DL- C显著降低 ( P<0 .0 5～ 0 .0 1) ,治疗期间无明显副作用发生。结论 :淡水鱼油对高血脂症和冠心病的防治具有优越性。

Objective:To investigate the effect of chinese fresh water fish oil on hyperlipidemia and metabolism of prastoglandin.Method:90 patients with hyperlipidemia were double blind randomized into 2 groups,46 in fresh water fish oil group(fresh water fish oil 10～15 ml,tid)and 44 in Control (VitE 150 mg/d).Result:After medication for 4～8 weeks the concentrations of EPA and DHA in plasma and erythrocyte were significantly increased.While Chinese fresh water fish oil produced a significant reduction in levels of Lp(a) (P< 0.05 ),increase in levels of apoAI,PGF 1α (P< 0.01 ),TC,TG,LDL C (P< 0.01 ),compared with pre and post treatment sample and controls.During the treatment of the fish oil there was no significantly side actions.Conclusion:These results suggested the fresh water fish oil had benifit in prevention and treatment of hyperlipidemia.