苯那普利对急性心肌梗死心功能远期恢复的影响

Influence of Benazepril on remote recovery of myocardial function in patients with acute myocardial infarction

目的 :探讨苯那普利对急性心肌梗死 ( AMI)心功能远期恢复的影响。方法 :选择 70例AMI患者 ,随机分为两组 ,每组 35例 ,分别给予常规治疗和常规治疗加苯那普利治疗 ( 10 mg/次 ,每日 1次 ,长期服用 )。两组分别在梗死后 4周和 6个月进行核素心肌显像及核素心室造影 ,测定心功能。结果 :在 AMI恢复期内 ,心肌灌注及心功能仍有所改善 ,苯那普利治疗组心功能改善明显优于常规治疗组。结论 :AMI患者心功能恢复需一较长时间 ,苯那普利有利于梗死后心功能的远期恢复。

Objective:To investigate the remote changes of myocardial function in patients with acute myocardial infarction and the influence of Benazepril treatment.Method:Seventy consecutive male patients (53±8 years old) with recent anterior myocardial infarction were consisted and were divided into two groups randomly each group contained 35 cases.One group was treated with routine therapy including nitrates,asprin,β blockers,heparin and named as group A.The other group was treated with routine therapy as above add Benazepril 10 mg once daily and named as group B.Myocardial ischemic areas and function were measured at 4 weeks and 6 months after myocardial infarction by 99m TC MIBI myocardial perfusing tomography and cardioventriculography with Sopha DST single photon emission computed tomography made in France.Result:There was no significant difference in ischemic areas between the two groups at 4 weeks after MI.The values of LVEF(%) at 4 week and 6 month were ( 43.31 ± 8.02 ) vs ( 46.18 ± 9.21 ) (P< 0.05 ) in group A and ( 43.01 ± 9.87 ) vs ( 55.41 ± 6.54 ) (P< 0.05 ) in group B.There was a significant difference between group A and B at 6 month after MI (P< 0.05 ).Conclusion:The recovery of myocardial function needs a long time and treatment with Benazepril may improve the remote recovery of myocardial function after myocardial infarction.