糖肽类抗生素替考拉宁的研究进展

RECENT ADVANCE OF TEICOPLANIN

替考拉宁是糖肽类抗生素，与万古霉素比较具有更强的脂溶性，半衰期更长，对金葡菌的抗菌活性与万古霉素相似，对肠球菌的抗菌活性强于万古霉素。具有良好的组织、体液分布性，药物不良反应轻。可静脉或肌肉给药，治疗金葡菌和肠球菌引起的各种感染有良好的效果。

Teicoplanin was a glycopeptide antibiotic which had excellent bactericidal activity in vitro against Gram-positive aerobic and anaerobic bacteria. It was more active against enterococci and methicillin-resistant staphylococci. Teicoplanin had a longer T1/2β,and can be administered intravenously or intramuscularly, readily distributed into interstitial fluid producing concentration in tissue likely to be clinically effective. The clinical trials showed teicoplanin was effective on treatment of severe bacterial skin and soft tissue infection, bacterial infections is the lower respiratory tract, bacteraemia and intravascular infection and infections with neutropenia. The frequently reported adverse vents were diarrhoea, rash, nausea and vomiting and changing in hepatic biochemistry. Importantly, teicoplanin has a lesser propensity than vancomycin to cause renal impairment.