MEF2A基因CAG三核苷酸重复序列与冠状动脉病变及严重程度的相关性

The Association Between CAG Repeat Number Polymorphism in MEF2A Gene and Severity of Coronary Artery Disease

目的探讨北京地区汉族人群中MEF2A基因CAG三核苷酸重复序列与冠状动脉病变及严重程度的相关性。方法用聚合酶链反应产物直接测序法对所有研究对象进行MEF2A基因11号外显子测序,用病例-对照方法研究CAG重复序列与冠状动脉病变支数的相关性。结果在473例冠心病病例和303例对照中,MEF2A基因11号外显子CAG重复序列存在多态性,按照不同遗传模式分析,4～8个CAG重复序列均与冠状动脉病变支数无明显相关性。结论 MEF2A基因11号外显子4～8个CAG重复序列和北京地区汉族人群中冠状动脉病变的严重程度无明显相关性。

Aim To investigate the association between CAG polymorphism sites of MEF2A and severity of coronary artery disease in Han nationality of BeiJINg. Methods Using PCR sequencing method to investigate the genotype of exon 11 of MEF2A of all subjects. Case-control study was used to detect the association of the genotype of 4～8 CAG repeat number with the severity of coronary artery disease. Results In 473 coronary artery disease patients and 303 control individuals,CAG repeat number of exon 11 of MEF2A had polymorphism. Under different heredity mode,there was no significant association between 4～8 CAG repeat number and severity of coronary artery disease. Conclusion The genotype of 4～8 CAG repeat number of the exon 11 of MEF2A gene has no significant association with severity of coronary artery disease in Han nationality of BeiJINg.