脂联素与2型糖尿病动脉粥样硬化的相关性

Relationship of Serum Adiponectin and Atherosclerosis in Type 2 Diabetic Patients

目的探讨2型糖尿病患者血清脂联素和动脉粥样硬化病变程度的相关性。方法 90例缺血性脑血管病患者按2型糖尿病诊断标准分为2型糖尿病组(47例)和非糖尿病组(43例)。2型糖尿病组又分为轻度狭窄组(n=12)、中度狭窄组(n=27)和重度狭窄组(n=8)。采用脑血管造影法评估颈动脉狭窄的程度,测定脂联素、空腹血糖和高敏C反应蛋白水平。结果 2型糖尿病组脂联素水平显著下降,高敏C反应蛋白、空腹血糖水平显著升高,与非糖尿病组比较差异有显著性(P<0.05)。与轻度狭窄组比较,中、重度狭窄组脂联素水平显著下降,高敏C反应蛋白水平显著上升(P<0.05);与中度狭窄组比较,重度狭窄组脂联素水平显著下降,高敏C反应蛋白水平显著上升(P<0.05);脂联素水平与高敏C反应蛋白水平和颈动脉受累程度呈显著负相关(r=-0.4692,-0.3925,P<0.01),而高敏C反应蛋白水平与颈动脉受累程度呈显著正相关(r=0.8925,P<0.01)。结论低脂联素水平与颈动脉血管狭窄程度有良好的相关性,低脂联素水平是预测糖尿病患者并发生颈动脉粥样硬化以及病变发展程度的良好指标。

Aim To investigate the relationship of serum adiponectin and atherosclerosis（As） in type 2 diabetic patients （T2DM）. Methods 90 patients of ischemic cerebrovascular disease were divided into type 2 diabetes group （47 cases） and non-diabetic group （43 cases） according to diagnostic criteria of T2DM and carotid artery lesions. Type 2 diabetes group＇s patients were divided into mild stenosis group （12 cases）,moderate stenosis group （27 cases） and severe stenosis group （8 cases）. The extent of coronary artery stenosis was evaluated by cerebral angiography,the serum adiponectin,fasting blood glucose and high sensitivity C-reactive protein （hs-CRP） levels were detected. Results The adiponectin levels of type 2 diabetes group was significantly lower,the fasting blood glucose and hs-CRP of lesion group significantly increased,compared with the no lesion group （P〈0.05）; The adiponectin levels of moderate and severe stenosis group was significantly lower,the fasting blood glucose and hs-CRP of moderate and severe stenosis group significantly increased,compared with the mild stenosis group （P〈0.05）; The adiponectin levels of severe stenosis group was significantly lower,the fasting blood glucose and hs-CRP of severe stenosis group significantly increased,compared with the moderate stenosis group （P〈0.05）. The adiponectin levels and hs-CRP levels and degree of arterial involvement was significantly negatively correlated （r=-0.469 2,-0.392 5,P〈0.01）,while the hs-CRP levels and degree of arterial involvement were significantly correlated （r=0.892 5,P〈0.01）. Conclusion The adiponectin levels and carotid artery stenosis has a good correlation,the low adiponectin levels is a good indicator for predicting the diabetic patients,the occurrence of coronary atherosclerosis and the extent of lesion development.