期刊文献+

脂联素与2型糖尿病动脉粥样硬化的相关性 被引量:1

Relationship of Serum Adiponectin and Atherosclerosis in Type 2 Diabetic Patients
下载PDF
导出
摘要 目的探讨2型糖尿病患者血清脂联素和动脉粥样硬化病变程度的相关性。方法 90例缺血性脑血管病患者按2型糖尿病诊断标准分为2型糖尿病组(47例)和非糖尿病组(43例)。2型糖尿病组又分为轻度狭窄组(n=12)、中度狭窄组(n=27)和重度狭窄组(n=8)。采用脑血管造影法评估颈动脉狭窄的程度,测定脂联素、空腹血糖和高敏C反应蛋白水平。结果 2型糖尿病组脂联素水平显著下降,高敏C反应蛋白、空腹血糖水平显著升高,与非糖尿病组比较差异有显著性(P<0.05)。与轻度狭窄组比较,中、重度狭窄组脂联素水平显著下降,高敏C反应蛋白水平显著上升(P<0.05);与中度狭窄组比较,重度狭窄组脂联素水平显著下降,高敏C反应蛋白水平显著上升(P<0.05);脂联素水平与高敏C反应蛋白水平和颈动脉受累程度呈显著负相关(r=-0.4692,-0.3925,P<0.01),而高敏C反应蛋白水平与颈动脉受累程度呈显著正相关(r=0.8925,P<0.01)。结论低脂联素水平与颈动脉血管狭窄程度有良好的相关性,低脂联素水平是预测糖尿病患者并发生颈动脉粥样硬化以及病变发展程度的良好指标。 Aim To investigate the relationship of serum adiponectin and atherosclerosis(As) in type 2 diabetic patients (T2DM). Methods 90 patients of ischemic cerebrovascular disease were divided into type 2 diabetes group (47 cases) and non-diabetic group (43 cases) according to diagnostic criteria of T2DM and carotid artery lesions. Type 2 diabetes group's patients were divided into mild stenosis group (12 cases),moderate stenosis group (27 cases) and severe stenosis group (8 cases). The extent of coronary artery stenosis was evaluated by cerebral angiography,the serum adiponectin,fasting blood glucose and high sensitivity C-reactive protein (hs-CRP) levels were detected. Results The adiponectin levels of type 2 diabetes group was significantly lower,the fasting blood glucose and hs-CRP of lesion group significantly increased,compared with the no lesion group (P〈0.05); The adiponectin levels of moderate and severe stenosis group was significantly lower,the fasting blood glucose and hs-CRP of moderate and severe stenosis group significantly increased,compared with the mild stenosis group (P〈0.05); The adiponectin levels of severe stenosis group was significantly lower,the fasting blood glucose and hs-CRP of severe stenosis group significantly increased,compared with the moderate stenosis group (P〈0.05). The adiponectin levels and hs-CRP levels and degree of arterial involvement was significantly negatively correlated (r=-0.469 2,-0.392 5,P〈0.01),while the hs-CRP levels and degree of arterial involvement were significantly correlated (r=0.892 5,P〈0.01). Conclusion The adiponectin levels and carotid artery stenosis has a good correlation,the low adiponectin levels is a good indicator for predicting the diabetic patients,the occurrence of coronary atherosclerosis and the extent of lesion development.
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2010年第4期319-321,共3页 Chinese Journal of Arteriosclerosis
关键词 脂联素 2型糖尿病 动脉粥样硬化 Serum Adiponectin Type 2 Diabetes Atherosclerosis
  • 相关文献

参考文献8

  • 1邹继红,史兆荣.老年2型糖尿病脂联素和C反应蛋白与动脉粥样硬化的关系[J].中华老年心脑血管病杂志,2007,9(9):599-601. 被引量:12
  • 2付效国,王桂清,盖春莲.2型糖尿病家系一级亲属腰围与血清脂联素、胰岛素抵抗和动脉粥样硬化相关性研究[J].第四军医大学学报,2009,30(4):383-384. 被引量:4
  • 3廖二元,超楚生.内分泌学,第1版[M].北京:人民卫生出版社.2001:1562.
  • 4lwaki M, Matsuda M, Maeda N, ct al. Induction of adiponectin,a fat-derived anfidiabetic and antiatherogenic factor,by nuclear receptor [J]. Diabetes, 2003, 52 : 1 655-663.
  • 5Kirsten AM, Sheila MW, Jim I M, et al. Diagnosing insulin resistance in the general population [ J]. Diabetes Care, 2001,24: 460-464.
  • 6Chart KC, Chou HH, Wu DJ, et al. Diabetes mellitus has an additional effect on coronary artery disease [J]. Jpn Heart J, 2004, 45 (6) : 921- 927.
  • 7Lihn AS, Ostergard T, Nyholm B, et al. Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients [J]. Am J Physiol Endocrinol Metab , 2003,284 (2) : 443-448.
  • 8Yamauchi T, Kamon J, Waki H, et al. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis [J]. J Biol Chem, 2003 , 78 ( 4 ) : 2 461-468.

二级参考文献6

  • 1李全民,张素华,任伟,倪银星,吴静,赵同峰,詹志伟.2型糖尿病家系人群中三代成员糖尿病患病危险因素:183个家族497人调查[J].中国临床康复,2005,9(35):12-14. 被引量:7
  • 2Arita Y, Kihara S, Ouchi N, et al . Adipocyte derived plasma protein adiponectin acts as a platelet-derived growth factor BB binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell[J]. Circulation,2002,105:2893-2898.
  • 3Hirose H, Kawai T, Yamamato Y, el al. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabe tes[J]. Metabolism,2002,51:314-317.
  • 4Yaturu S, Bridges JF.Reddy DR. Decreased levels of plasma adiponectin in prediabetes,type 2 diabetes and coronary artery disease[J]. Med Sci Monit, 2006,12 :CR17-CR20.
  • 5Fantuzzi G. Adipose tissue, adipokines, and inflammation[J]. J Allergy Clin Immunol,2005,115:911-919.
  • 6Furuta M,Tamai M, Hanabusa T, et al. Serum adiponectin is associated with fasting serum C peptide in non obese diabetic patients[J]. Diabetes Res Clin Pract,2006,72:302-307.

共引文献15

同被引文献16

  • 1刘金波,邓华聪,葛倩,李丙蓉,郑宏庭,兰丽珍.脂联素对TNF-α介导的血管炎症反应的影响[J].第四军医大学学报,2006,27(18):1697-1699. 被引量:19
  • 2李新立,童敏,徐琼,卢新政,王震震,周艳丽,张海锋,曹克将,黄峻.平均动脉压水平与血清脂联素浓度相关性研究[J].中华心血管病杂志,2007,35(4):320-324. 被引量:10
  • 3陈仁涉,高芳坤,魏洁.微量白蛋白尿的发生机理、预后及治疗[J].国外医学(临床生物化学与检验学分册),1997,18(4):156-158. 被引量:52
  • 4Jay PG, Geoge LB. Microalbuminuria:marker of vascular dysfunction, risk factor for cardiovascular disease [ J ]. Vascular Medicine, 2002,7 ( 1 ) :35-43.
  • 5Parikh A, Daneman D. Is carotid ultrasound a useful tool in assessing cardiovascular disease in individuals with diabetes [ J ] ? Diabetes Teehnol Ther, 2004,6( 1 ) :65-69.
  • 6Knobler H, Banderly M, Boyko V, et al. Adiponeetin and the devel- opment of diabetes in pitents with coronary artery disease and impaired fasting glucose[ J]. Eur J Endocrinal,2006,154( 1 ) :87-92.
  • 7Matsuda M, Shimomura I, Sata M, et al. Role of adiponectin in pre- venting vascular stenosis, the missing link of adipo-vascular axis [ J ]. J Biol Chem,2002,277 (22) :37487-37491.
  • 8Massiera F, Bloch-Faure M, Ceiler D, et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation [ J ]. FASEB ,2001,15 (14) :2727-2729.
  • 9Fasshauer M, Klein J, Neumann S, et al. Adiponectin gene expression is inhabited by beta-adrenergic stimulation via protein kinase A in 313 L1 adipocytes[ J]. FEBS Lett, 2001,507 (2) : 142-146.
  • 10Lange LA, Bowden DW, Langefeld CD, et al. Heritability of carotid artery intima -medial thickness in type 2 diabetes [ J ]. Stroke ,2002,33 (7) :1876-1881.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部