血液透析患者血清肿瘤标志物的检测及临床意义

Detection and Clinical Value of Serum Tumor Markers in Hemodialysis Patients

目的:观察血液透析(血透)患者血清肿瘤标志物CEA、CA19-9、NSE、CA242、Ferritin、β-HCG、AFP、HGH、CA153、CA125、PSA、fPSA的临床意义。方法:选择143例维持性血透患者作为血透组、143例未行血透的尿毒症患者(CKD5期)作为非透析组,并选择429例健康人作为对照组。将血透组按血透维持时间分为两个亚组比较:A组,维持性透析时间超过3月;B组,维持性透析时间少于3月。结果:血透组和非透析组比较,Ferritin水平差异有统计学意义,其他各肿瘤标志物水平差异无统计学意义(P>0.05);血透组、非透析组与对照组比较肿瘤标志物Ferritin、CA19-9、CA125的水平差异有统计学意义(P<0.05);其他肿瘤标志物的差异无统计学意义(P>0.05)。透析组的两个亚组肿瘤标志物水平差异无统计学意义。结论:尿毒症和血透患者肿瘤标志物Ferritin、CA19-9、CA125有不同程度的升高,血透不能清除肿瘤标志物。

Objective：To assesses the clinical value of tumor markers including CEA,CA19-9,NSE,CA242,Ferritin,β-HCG,AFP,HGH,CA153,CA125,PSA,and fPSA in haemodialysis patients.Methods：We assigned 143 patients receiving maintenance hemodialysis into the hemodialysis group,143 patients with uremia who did not receive hemodialysis into the non-hemodialysis group,and 429 healthy people into the control group.Patients in hemodialysis group were further divided into two subgroups according to the duration of hemodialysis,and serum levels of tumor markers were compared between the two subgroups.Results：There were statistically significant differences in Ferritin,but not in any of the other tumor markers between hemodialysis and non-hemodialysis groups（P〉0.05）.The serum levels of CA199,CA125 and Ferritin in two groups and the control groups had statistical significance（P〈0.05）.There were no significant differences in serum levels of other tumor markers（P〉0.05）.There were no significant differences in serum levels of any tumor marker between two subgroups within hemodialysis group.Conclusion：Ferritin,CA19-9 and CA125 were elevated to various degrees in patients with uremia who were receiving hemodialysis or not receiving hemodialysis.Hemodialysis was not to eleminate tumor markers.